E-Book Overview
Mice have been domesticated by humans for centuries, even millennia, and have been used in research since the 1600's. However, development of the laboratory mouse as a research model accelerated with genetic experiments in the early 1900's. Today, the laboratory mouse is recognized as the pre-eminent model for modern genetic research. In fact, over the last decade or so, most biomedical research facilities have experienced increases of up to three hundred percent in their mouse populations. Numerous other disciplines, including immunology, cancer biology, toxicology, developmental biology, aging research, and cardiovascular biology have recognized the mouse as a valuable research model. The Laboratory Mouse provides a single source reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in biomedical research. The book is particularly valuable to researchers at small institutions and to those who work at facilities that lack large, well-organized animal resource units.
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A Volume in The Laboratory Animal Pocket Reference Series
The Laboratory
MOUSE Mark A. Suckow, D.V.M. Peggy Danneman, V.M.D. Cory Brayton, D.V.M.
CRC Press Boca Raton London New York Washington, D.C.
disclaimer Page 1 Thursday, November 16, 2000 5:11 PM
Library of Congress Cataloging-in-Publication Data Suckow, Mark A. The laboratory mouse / Mark A. Suckow, Peggy Danneman, Cory Brayton. p. cm.— (Laboratory animal pocket reference series) Includes bibliographical references and index (p. ). ISBN 0-8493-0322-2 (alk. paper) 1. Mice as laboratory animals. I. Danneman, Peggy. II. Brayton, Cory. III. Title. IV. Series. SF407.M5 S83 2000 636.088′5—dc21
00-05072
This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC, 2000 N.W. Corporate Blvd., Boca Raton, Florida 33431, or visit our Web site at www.crcpress.com Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe.
© 2001 by CRC Press LLC No claim to original U.S. Government works International Standard Book Number 0-8493-0322-2 Library of Congress Card Number 00-050724 Printed in the United States of America 1 2 3 4 5 6 7 8 9 0 Printed on acid-free paper
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preface The use of laboratory animals, including mice, continues to be an important part of biomedical research. Individuals performing such research are often charged with broad responsibilities, including animal facility management, animal husbandry, regulatory compliance, and performance of technical procedures directly related to research projects. This handbook was written to provide a quick reference for investigators, technicians, and animal caretakers charged with the care or use of mice in a research s