Academic Press is an imprint of Elsevier 32 Jamestown Road, London, NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2010 Copyright © 2010 Elsevier Inc. All rights reserved No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email:
[email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library ISBN: 978-0-12-381027-4 ISSN: 0065-2458 For information on all Academic Press publications visit our web site at elsevierdirect.com Printed and bound in USA 10 11 12 10 9 8 7 6 5 4 3 2 1
Contributors
Dr. Joshua N. Adkins is a Staff Scientist at Pacific Northwest National Laboratory (PNNL) and his research centers on the comprehensive characterization of proteins through space (associated proteins, structural determinants, and localization) and time (before and after treatment, cell cycle, day–night cycle, and evolutionary changes) to better understand biological systems. Of particular interest to Dr. Adkins are challenging biological studies that require bridging the gaps between technology development and biological application. He leads a talented and multidisciplinary team comprised of scientists from PNNL, universities, and other research organizations whose aim is to develop a systems-level understand of the causative agents of Typhoid Fever and the Black Plague. Douglas J. Baxter is a Senior Research Scientist at the Department of Energy’s Pacific Northwest National Laboratory working as a consultant in the Visualization and User services group for the Molecular Science Computing Facility in the Environment Molecular Sciences Laboratory. He has been developing software for parallel high-performance scientific computing for over 25 years and has currently involved in computational biology (MSPolygraph and Scalablast), some climate modeling, subsurface chemistry, and power grid computations. He received his M.S. in Computer Science from Stanford University. Dr. William R. Cannon joined PNNL in January 2