Cytokines (growth Factors & Cytokines In Health & Disease)

GROWTH FACTORS AND CYTOKINES IN HEALTH AND DISEASE A Multi-Volume Treatise Volume 2B • CYTOKINES 1997 This Page Intentionally Left Blank GROWTH FACTORS AND CYTOKINES IN HEALTH AND DISEASE A Multi-Volume Treatise CYTOKINES Editors: DEREK LEROITH Diabetes Branch NIDDK National Institutes of Health Bethesda, Maryland CAROLYN BONDY Developmental Endocrinology Branch NICHD National Inatitutes of Health Bethesda, Maryland VOLUME 2B • 1997 \M) @ Greenwich, Connecticut JAI PRESS INC. London, England Copyright © 1997 JAI PRESS INC. 55 Old Post Road No. 2 Greenwich, Connecticut 06836 JAI PRESS LTD. 38 Tavistock Street Covent Garden London WC2E 7PB England All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any way, or by any means, electronic, mechanical, photocopying, recording, filming or otherwise without prior permission in writing from the publisher. ISBN: 0'7623-0117-l Manufactured in the United States of America CONTENTS LIST OF CONTRIBUTORS ix PREFACE Derek LeRoith and Carolyn Bondy xiii PARTB THE TYPE I INTERFERON RECEPTOR COMPLEX Sidney Pestka 403 INTERFERON-BETA: STRUCTURE, DIFFERENTIAL ACTIONS, AND MEDICAL APPLICATIONS Michel Revel 433 THE MOLECULAR BASIS OF IFNy ACTION Anand S. Dighe, Erika A. Bach, Andrew C. Greenland, and Robert D. Schreiber 521 CYTOKINES: GRANULOCYTE COLONY-STIMULATING FACTOR Judith E. Layton, Sandra Nicholson, Russell Basser, and Jonathan Cebon LEUKEMIA INHIBITORY FACTOR AND ITS RECEPTOR Nicos A. Nicola and Douglas J. Hilton TUMOR NECROSIS FACTOR Matthias Crell and Peter Scheurich 557 613 669 vi CONTENTS LYMPHOTOXIN: DEVELOPMENTS DURING THE LAST DECADE Bharat B. Aggarwal and Sanjaya Singh IL-6, IL-11, LIE, OSM, CARDIOTROPHIN-1 AND CNTF: AN EXAMPLE OF A CYTOKINE FAMILY SHARING SIGNAL TRANSDUCTING RECEPTOR COMPONENTS Neil Stahl and George D. Yancopoulos INDEX 727 777 811 CONTENTS LIST OF CONTRIBUTORS ix PREFACE Derek LeRoith and Carolyn Bondy xiii PART A lNTERLEUKIN-2 Michael T. Lotze 1 INTERLEUKIN-3 John W. Schrader 49 INTERLEUKIN-4 Jaques Banchereau and Sem Saeland 85 INTERLEUKIN-5 Kiyoshi Takatsu, Richard R. Dickason, and David P. Huston 143 INTERLEUKIN-6 Chun-fai Lai and Heinz Baumann 201 THE ROLE OF INTERLEUKIN-7 (IL-7) IN THE GENERATION AND REGULATION OF IMMUNE RESPONSES David H. Lynch 257 VII viii THE BIOLOGICAL, BIOCHEMICAL, AND MOLECULAR PROFILE OF LEUKOCYTE CHEMOTACTIC AND ACTIVATING CYTOKINE, INTERLEUKIN-8 Akihisa Harada, Naofumi Mukaida, and Kouji Matsushima INTERLEUKIN-10 Alexander H. Enk THE INTERLEUKIN-2 RECEPTOR Mark A. Goldsmith and Warner C. Creene CONTENTS 277 319 355 LIST OF CONTRIBUTORS Bharat B. Aggarwal Cytokine Research Laboratory The University of Texas, Houston Erika A. Bach Center for Immunology Washington University School of Medicine Jacques Banchereau Schering-Plough Laboratory for Immunological Research Dardllly, France Russell Basser Centre for Developmental Cancer Therapeutics Royal Melbourne Hospital Heinz Baumann Department of Molecular and Cellular Biology Roswell Park Cancer Institute Buffalo, New York Jonathan Cebon Centre for Developmental Cancer Therapeutics Royal Melbourne Hospital Richard R. Dickason Departments of Medicine, Microbiology, and Immunology Baylor College of Medicine Anand S. Dighe Center for Immunology Washington University