Il-1 Receptor Type I

Download

E-Book Overview

The IL-1 receptor type I is the ligand-binding chain of the IL-1 heterodimer complex. It is a three-domain Ig-like extracellular receptor with a cytoplasmic domain containing the Toll protein-like sequences. The IL-1 R type I does not function without the second chain of the dimer, namely the IL-1R accessory protein. Although the IL-1R accessory proteinchain does contain similar extracellular domains as the type I, it does not bind IL-1 in solution. However, the IL-1R accessory protein, together with the IL-1RI, form a complex with the IL-1 ligand (IL-1♂ or IL-1♀) with a high affinity. Soluble forms of the IL-1RI, produced by proteolytic cleavage, are found in the circulation of healthy humans and in elevated levels during disease. The soluble IL-1RI has an unusually high binding constant to the IL-1Ra and hence with preferentially bind this antagonist member of the IL-1 family. Although in animals administration of soluble IL-1RI has reduced the severity of disease, in humans with rheumatoid arthritis this method of neutralizing IL-1 has not been successful because it binds IL-1Ra before it binds IL-1♂ or IL-1♀.

E-Book Content

IL-1 Receptor Type I Charles A. Dinarello* Department of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B168, Denver, CO 80262, USA * corresponding author tel: 303-315-3589, fax: 303-315-8054, e-mail: [email protected] DOI: 10.1006/rwcy.2000.15001. SUMMARY The IL-1 receptor type I is the ligand-binding chain of the IL-1 heterodimer complex. It is a three-domain Ig-like extracellular receptor with a cytoplasmic domain containing the Toll protein-like sequences. The IL-1 R type I does not function without the second chain of the dimer, namely the IL-1R accessory protein. Although
You might also like

Robot Mechanisms And Mechanical Devices Illustrated
Authors: Paul Sandin    200    0

Lessons In Electric Circuits 1 - Dc
Authors: Kuphaldt.    141    0

The Laser Guidebook
Authors: Jeff Hecht    153    0

Woodworking Shopnotes 085 - Cutting Diagram
   182    0

Heat Transfer: A Practical Approach
Authors: Yunus A. Cengel , Yunus Cengel    152    0

Il-5 Receptor
Authors: Bagley Ch.J. , Tavernier J. , Woodcock J.M.    205    0

Fracture And Size Effect In Concrete And Other Quasibrittle Materials
Authors: Zdenek P. Bazant , Jaime Planas    145    0

Compressors: Selection And Sizing
Authors: Royce N. Brown    151    0

Rf Components And Circuits
Authors: Joe Carr    181    0

Advanced Bash-scripting Guide. A Complete Guide To Shell Scripting
Authors: Cooper M.    202    0