IL-5 Receptor Christopher J. Bagley1,2,*, Jan Tavernier 3, Joanna M. Woodcock 4,2 and Angel F. Lopez 4,2 1
Protein Laboratory, Hanson Centre for Cancer Research, Frome Road, Adelaide, SA, 5000, Australia 2 Human Immunology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA, 5000, Australia 3 Department of Medical Protein Research, Flanders' Interuniversity Institute for Biotechnology, University of Ghent, Ghent, Belgium 4 Cytokine Receptor Laboratory, Hanson Centre for Cancer Research, Frome Road, Adelaide, SA, 5000, Australia * corresponding author tel: 61-8-82223714, fax: 61-8-82324092, e-mail:
[email protected] DOI: 10.1006/rwcy.2000.20002.
SUMMARY The receptor for IL-5 is comprised of two chains: an chain that binds IL-5 with moderate affinity but alone is unable to mediate signaling, and a chain that represents the major signaling component of the receptor. The chain is unable to bind IL-5 alone, but when expressed together with the IL-5 receptor chain (IL-5R ) a high-affinity receptor is formed (Kd 0.15 nM). The chain is shared with the related receptors for granulocyte±macrophage colony-stimulating factor (GM-CSF) and IL-3 and many of the events in IL-5-induced signal transduction are paralleled in the GM-CSF and IL-3 receptors. The IL-5R is expressed on a restricted range of cell types, principally eosinophils, basophils, and their immediate precursors confining the actions of IL-5 to these cells. Thus, the IL-5 receptor is considered to be a target in the development of treatments for allergic inflammatory diseases such as asthma.
BACKGROUND
Tavernier et al. (1991) who also identified the chain of the GM-CSF receptor ( c, cloned by Hayashida et al., 1990) as a component of the IL-5R.