E-Book Overview
Helping researchers predict drug interactions in a more accurate and effective manner, this comprehensive volume covers every critical aspect of metabolism-based drug-drug interactions, including preclinical, clinical, toxicological, regulatory, and marketing perspectives by renowned thought leaders in their respective fields. Thoroughly updated, the Second Edition reflects key developments in the field, including an improved understanding of the relationship between transporters and enzymes in drug metabolism and drug interactions. Formatted to benefit the reader, this source provides helpful case examples, representative enzyme systems, and computer-aided modeling, as well as 200 valuable tables, equations, drawings, and photographs to clarify key concepts
E-Book Content
Drug-Drug Interactions
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Drug-Drug Interactions Second Edition
Edited by
A. David Rodrigues
Bristol-Myers Squibb Research & Development Princeton, New Jersey, USA
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1/7/08 10:03:47 AM
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DRUGS AND THE PHARMACEUTICAL SCIENCES A Series of Textbooks and Monographs
Executive Editor James Swarbrick PharmaceuTech, Inc. Pinehurst, North Carolina
Advisory Board Larry L. Augsburger University of Maryland Baltimore, Maryland
Jennifer B. Dressman University of Frankfurt Institute of Pharmaceutical Technology Frankfurt, Germany
Anthony J. Hickey University of North Carolina School of Pharmacy Chapel Hill, North Carolina
Ajaz Hussain Sandoz Princeton, New Jersey
Joseph W. Polli GlaxoSmithKline Research Triangle Park, North Carolina
Stephen G. Schulman
Harry G. Brittain Center for Pharmaceutical Physics Milford, New Jersey
Robert Gurny Universite de Geneve Geneve, Switzerland
Jeffrey A. Hughes University of Florida College of Pharmacy Gainesville, Florida
Vincent H. L. Lee US FDA Center for Drug Evaluation and Research Los Angeles, California
Kinam Park Purdue University West Lafayette, Indiana
Jerome P. Skelly
University of Florida Gainesville, Florida
Alexandria, Virginia
Yuichi Sugiyama
University of Kansas Lawrence, Kansas
University of Tokyo, Tokyo, Japan
Geoffrey T. Tucker University of Sheffield Royal Hallamshire Hospital Sheffield, United Kingdom
Elizabeth M. Topp
Peter York University of Bradford School of Pharmacy Bradford, United Kingdom
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1. Pharmacokinetics, Milo Gibaldi and Donald Perrier 2. Good Manufacturing Practices for Pharmaceuticals: A Plan for Total Quality Control, Sidney H. Willig, Murray M. Tuckerman, and William S. Hitchings IV 3. Microencapsulation, edited by J. R. Nixon 4. Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner 5. New Drugs: Discovery and Development, edited by Alan A. Rubin 6. Sustained and Controlled Release Drug Delivery Systems, edited by Joseph R. Robinson 7. Modern Pharmaceutics, edited by Gilbert S. Banker and Christopher T. Rhodes 8. Prescription Drugs in Short Supply: Case Histories, Michael A. Schwartz 9. Activated Charcoal: Antidotal and Other Medical Uses, David O. Cooney 10. Concepts in Drug Metabolism (in two parts), edited by Peter Jenner and Bernard Testa 11. Pharmaceutical Analysis: Modern Methods (in two parts), edited by James W. Munson 12. Techniques of Solubilization of Drugs, edited by Samuel H. Yalkowsky 13. Orphan