Treatment-resistant Depression

Treatment-resistant Depression Treatment-resistant Depression Edited by Siegfried Kasper, MD Professor and Chair, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria Stuart Montgomery, MD Emeritus Professor of Psychiatry, Professor of Psychiatry (retired), Imperial College of Science, Technology and Medicine, University of London, London, UK A John Wiley & Sons, Ltd., Publication This edition first published 2013, © 2013 by John Wiley & Sons, Ltd Wiley-Blackwell is an imprint of John Wiley & Sons, formed by the merger of Wiley’s global Scientific, Technical and Medical business with Blackwell Publishing. Registered Office John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial Offices 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 2121 State Avenue, Ames, Iowa 50014-8300, USA For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell. The right of the author to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. Limit of Liability/Disclaimer of Warranty: While the publisher and author(s) have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. It is sold on the understanding that the publisher is not engaged in rendering professional services and neither the publisher nor the author shall be liable for damages arising herefrom. If professional advice or other expert assistance is required, the services of a competent professional should be sought. Library of Congress Cataloging-in-Publication Data Treatment-resistant depression / [edited by] Siegfried Kasper, Stuart Montgomery. p. ; cm. Includes bibliographical references and index. ISBN 978-1-119-95290-9 (pbk.) I. Kasper, S. (Siegfried) II. Montgomery, S. A. [DNLM: 1. Depressive Disorder, Treatment-Resistant–therapy. 2. Antidepressive Agents–therapeutic use. 3. Psychotherapy. WM 171.5] 616.85′2706–dc23 2012043215 A catalogue record for this book is available from the British Library. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books. Cover image: © Mike Kiev, iStockphoto.com. Cover design by Sarah Dickinson. Set in 10.5/12.5pt Times by SPi Publisher Services, Pondicherry, India 1 2013 Contents List of Contributors Foreword 1 Definitions and Predictors of Treatment-resistant Depression Daniel Souery and William Pitchot 2 Treatment-resistant Depression: A Separate Disorder – A New Approach Hans-Jürgen Möller, Florian Seemüller, Rebecca Schennach and Ramesh K. Gupta 3 Genetics of Treatment-resistant Depression Chiara Fabbri, Stefano Porcelli and Alessandro Serretti 4 Is There a Role for Switching Antidepressants in