E-Book Overview
Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair.
This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications.
The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tendon repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy.
Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.
E-Book Content
Lecture Notes in Bioengineering
José Fábio Santos Duarte Lana Maria Helena Andrade Santana William Dias Belangero Angela Cristina Malheiros Luzo Editors
Platelet-Rich Plasma Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries
Lecture Notes in Bioengineering
For further volumes: http://www.springer.com/series/11564
José Fábio Santos Duarte Lana Maria Helena Andrade Santana William Dias Belangero Angela Cristina Malheiros Luzo •
Editors
Platelet-Rich Plasma Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries
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Editors José Fábio Santos Duarte Lana Research Institute of Sports Medicine Orthopedics and Regeneration—iMOR Uberaba, MG Brazil and Member of the Regenerative and Cell Therapy Group, Hemocentro University of Campinas, Unicamp Campinas, SP Brazil
William Dias Belangero Department of Orthopaedic and Traumatology, Faculty of Medical Sciences University of Campinas Campinas, SP Brazil Angela Cristina Malheiros Luzo Haematology and Hemotherapy Center Umbilical Cord Blood Bank University of Campinas Campinas, SP Brazil
Maria Helena Andrade Santana Department of Materials and Bioprocesses Engineering, School of Chemical Engineering University of Campinas Campinas, SP Brazil
ISSN 2195-271X ISBN 978-3-642-40116-9 DOI 10.1007/978-3-642-40117-6
ISSN 2195-2728 (electronic) ISBN 978-3-642-40117-6 (eBook)
Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013950744 Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfil