Advances in
IMMUNOLOGY VOLUME
106
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Advances in
IMMUNOLOGY VOLUME
106 Edited by
FREDERICK W. ALT Howard Hughes Medical Institute, Boston, Massachusetts, USA Associate Editors
K. FRANK AUSTEN Harvard Medical School, Boston, Massachusetts, USA
TASUKU HONJO Kyoto University, Kyoto, Japan
FRITZ MELCHERS University of Basel, Basel, Switzerland
JONATHAN W. UHR University of Texas, Dallas, Texas, USA
EMIL R. UNANUE Washington University, St. Louis, Missouri, USA
AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier
Academic Press is an imprint of Elsevier 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 32 Jamestown Road, London, NW1 7BY, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands First edition 2010 Copyright # 2010 Elsevier Inc. All rights reserved No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email:
[email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made ISBN: 978-0-12-381304-6 ISSN: 0065-2776 (series) For information on all Academic Press publications visit our website at elsevierdirect.com Printed and bound in USA 10 11 12 10 9 8 7 6 5 4 3 2 1
CONTENTS
Contributors
1. The Role of Innate Immunity in B Cell Acquisition of Antigen Within LNs
vii
1
Santiago F. Gonzalez, Michael P. Kuligowski, Lisa A. Pitcher, Ramon Roozendaal, and Michael C. Carroll 1. Introduction 2. FDC are a Major Reservoir for Membrane-Bound Antigen 3. How do Antigens Arrive at FDC? 4. Role of LN Resident DC in Transport of Antigen Acknowledgments References
2. Nuclear Receptors, Inflammation, and Neurodegenerative Diseases
2 2 7 12 16 16
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Kaoru Saijo, Andrea Crotti, and Christopher K. Glass 1. Introduction 2. Nuclear Receptors: Family Members and Molecular Functions 3. Immune Cells in the CNS—Microglia, Astrocytes, and Lymphocytes 4. Inflammatory Components of Neurodegenerative Diseases 5. Summary and Per