E-Book Overview
This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and written by top experts including: computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behavior in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations.
E-Book Content
Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches
RSC Biomolecular Sciences Editorial Board: Professor Stephen Neidle (Chairman), The School of Pharmacy, University of London, UK Dr Simon F Campbell CBE, FRS Dr Marius Clore, National Institutes of Health, USA Professor David M J Lilley FRS, University of Dundee, UK This Series is devoted to coverage of the interface between the chemical and biological sciences, especially structural biology, chemical biology, bio- and chemo-informatics, drug discovery and development, chemical enzymology and biophysical chemistry. Ideal as reference and state-of-the-art guides at the graduate and post-graduate level.
Titles in the Series: Biophysical and Structural Aspects of Bioenergetics Edited by Ma˚rten Wikstro¨m, University of Helsinki, Finland Computational and Structural Approaches to Drug Discovery: Ligand–Protein Interactions Edited by Robert M. Stroud and Janet Finer-Moore, University of California in San Francisco, San Francisco, CA, USA. Exploiting Chemical Diversity for Drug Discovery Edited by Paul A. Bartlett, Department of Chemistry, University of California, Berkeley, USA and Michael Entzeroth, S*Bio Pte Ltd, Singapore Metabolomics, Metabonomics and Metabolite Profiling Edited by William J. Griffiths, The School of Pharmacy, University of London, London, UK Protein–Carbohydrate Interactions in Infectious Disease Edited by Carole A. Bewley, National Institutes of Health, Bethesda, Maryland, USA Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches Edited by Victor Mun˜oz, Department of Chemistry and Biochemistry, University of Maryland, MD, USA Protein-Nucleic Acid Interactions: Structural Biology Edited by Phoebe A. Rice, Department of Biochemistry & Molecular Biology, The University of Chicago, Chicago IL, USA and Carl C. Correll, Dept of Biochemistry and Molecular Biology, Rosalind Franklin University, North Chicago, IL, USA Quadruplex Nucleic Acids Edited by Stephen Neidle, The School of Pharmacy, University of London, London, UK, and Shankar Balasubramanian, Department of Chemistry, University of Cambridge, Cambridge, UK Ribozymes and RNA Catalysis Edited by David M. J. Lilley FRS, University of Dundee, Dundee, UK, and Fritz Eckstein, MaxPlanck-Institut for Experimental Medicine, Goettingen, Germany Sequence-specific DNA Binding Agents Edited by Michael Waring, Department of Pharmacology, University of Cambridge, Cambridge, UK Structural Biology of Membrane Proteins Edited by Reinhard Grisshammer and Susan K. Buchanan, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland, USA Structure-based Drug Discovery: An Overview Edited by Roderick E. Hubbard, University of York, UK, and Vernalis (R&D) Ltd, Cambridge, UK Therapeutic Oligonucleotides Edited by Jens Kurreck, Institute for Chemistry and Biochemistry, Free University Berlin, Berlin, Germany Visit our website on www.rsc.org/biomolecularsciences For further information please contact: Sales and Customer Care, Royal Society of