Evidence-based Infectious Diseases, 2nd Edition (evidence-based Medicine)

Evidence-Based Infectious Diseases Evidence-Based Infectious Diseases, Second Edition Edited by Mark Loeb, Fiona Smaill and Marek Smieja © 2009 Blackwell Publishing Ltd. ISBN: 978-1-405-17026-0 Evidence-Based Infectious Diseases Edited by Mark Loeb BSc, MD, MSc, FRCPC Professor, Department of Pathology and Molecular Medicine & Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton, Ontario Canada Fiona Smaill MB, ChB, FRCPC Department Chair & Professor of Pathology and Molecular Medicine McMaster University Hamilton, Ontario Canada Marek Smieja MD, DIP, MSc, PhD, FRCPC Department of Pathology and Molecular Medicine McMaster University Hamilton, Ontario Canada Second Edition A John Wiley & Sons, Ltd., Publication This edition first published 2009, © 2009 by Blackwell Publishing Ltd Previous editions: 2004 BMJ Books is an imprint of BMJ Publishing Group Limited, used under licence by Blackwell Publishing which was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing programme has been merged with Wiley’s global Scientific, Technical and Medical business to form Wiley-Blackwell. Registered office: John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offices: 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley .com/wiley-blackwell The right of the author to be identified as the author of this work has been asserted in accordance with the Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books. Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought. The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting a specific m