Handbook Of Clinical Pediatric Endocrinology

Handbook of Clinical Pediatric Endocrinology This page intentionally left blank Handbook of Clinical Pediatric Endocrinology EDITED BY Charles G.D. Brook MA MD FRCP FRCPCH Emeritus Professor of Paediatric Endocrinology University College London London, UK Rosalind S. Brown MD CM Associate Professor of Pediatrics Harvard Medical School Director, Clinical Trials Research, Endocrine Division Children’s Hospital Boston Boston, MA, USA FIRST EDITION © 2008 Charles Brook, Rosalind Brown Blackwell Publishing, Inc., 350 Main Street, Malden, Massachusetts 02148-5020, USA Blackwell Publishing Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UK Blackwell Publishing Asia Pty Ltd, 550 Swanston Street, Carlton, Victoria 3053, Australia The right of the Author to be identified as the Author of this Work has been asserted in accordance with the Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. First published 2008 Library of Congress Cataloging-in-Publication Data Brook, C. G. D. (Charles Groves Darville) Handbook of clinical pediatric endocrinology / Charles G.D. Brook, Rosalind S. Brown. – 1st ed. p. ; cm. ISBN 978-1-4051-6109-1 1. Pediatric endocrinology–Handbooks, manuals, etc. I. Brown, Rosalind S. II. Title. [DNLM: 1. Endocrine System Diseases–Handbooks. 2. Adolescent. 3. Child. 4. Infant. WK 39 B871h 2008] RJ418.B727 2008 618.92⬘4–dc22 2007025837 ISBN-13: 978-1-4051-6109-1 A catalogue record for this title is available from the British Library Set in 8.75/12pt Meridien by Charon Tec Ltd (A Macmillan Company), Chennai, India Printed and bound in Singapore by Markono Print Media Pte Ltd Commissioning Editor: Alison Brown Editorial Assistant: Jennifer Seward Development Editor: Rob Blundell Production Controller: Debbie Wyer For further information on Blackwell Publishing, visit our website: http://www.blackwellpublishing.com The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry policy, and which has been manufactured from pulp processed using acid-free and elementary chlorine-free practices. Furthermore, the publisher ensures that the text paper and cover board used have met acceptable environmental accreditation standards. Blackwell Publishing makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check that any product mentioned in this publication is used in accordance with the prescribing information prepared by the manufacturers. The author and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this book. Contents Preface, vii 1 The Application of Science to Clinical Practice, 1 2 The Endocrine Problems of Infancy, 14 3 Problems of Growth in Childhood, 33 4 Problems of Puberty and Adolescence, 59 5 The Thyroid Gland, 84 6 The Adrenal Gland, 99 7 Disorders of Calcium and Bone Metabolism, 123 8 Wat