Advances in VIRUS RESEARCH VOLUME 38 ADVISORY BOARD DAVIDBALTIMORE PAULKAESBERG ROBERT M. CHANOCK BERNARD Moss PETERC. DOHERTY ERLING NORRBY BERNARD N. FIELDS H. J. GROSS AKIRAOYA J. J. SKEHEL B. D. HARRISON R. H. SYMONS M. H. V. VANREGENMORTEL Advances in VIRUS RESEARCH Edited by KARL MARAMOROSCH FREDERICK A. MURPHY Department of Entomology Rutgers University New Brunswick, New Jersey Center for Infectious Diseases Centers for Disease Control Atlanta, Georgia AARON J. SHATKIN Center for Advanced Biotechnology and Medicine Piscataway, New Jersey VOLUME 38 ACADEMIC PRESS, INC. Harcourt Brace Jovanovich,Publishers San Diego New York Boston London Sydney Tokyo Toronto This book is printed on acid-free paper. @ COPYRIGHT 0 1990 BY ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. ACADEMIC PRESS, INC. San Diego, California 92101 United Kingdom Edition published by ACADEMIC PRESS LIMITED 24-28 Oval Road, London NW I 7DX LIBRARY OF CONGRESS CATALOG CARD NUMBER: ISBN 0-12-039838-9 (alk. paper) PRINTED IN THE UNITED STATES OF AMERICA 90 91 92 93 9 8 7 6 5 4 3 2 I 53-1 1559 Molecular Biology of Rotaviruses A . R . BELLAMY AND G . W . BOTH ...................... I . Introduction . . . ...................... I1. Particle Structur I11. Gene/Protein Coding Assignments ................................ Iv. Viral Entry. Uncoating. and Morphogenesis V. Role of Specific Viral Proteins in Morphogenesis ................... ........................ VI . Viral Hemagglutinin VP4 VII. Other Structural Proteins .......................... VIII . Highlights and Future Directions ................... References . . . . . . . . . . . . . . . . . . 1 3 8 12 19 27 29 33 34 Molecular Biology of Varicella Zoster Virus JEFFREY M . OSTROVE 1. I1. I11. IV. V. VI . VII . VIII . IX . X. Introduction ... ................................. Biology of Varicella Zoster Virus . . . . . . . . . . . . . . . Virus Structure .................................................. VZV DNA . . . . . . . . . . . . . . . . . . . Genomic Organization ........................................... Restriction Endonuclease Maps ................................... Virally Encoded Proteins ..................... Gene Expression ................................. VZV Latency . . . . . . . . . . . . . . . Conclusions ..................................................... References . . . . . ................. 45 47 51 52 54 57 61 75 86 91 91 Structure and Function of the RNA Polymerase of Vesicular Stomatitis Virus AMIYAK . BANERJEEAND DHRUBAJYOTI CHATTOPADHYAY I. I1. I11. Iv. V. VI . VII . Introduction . . . . . . . .................... Polypeptide Composition of VSV Transcription Complex Some Characteristic Features of the in Vitro Transcription Reaction L Protein ......... ............... Phosphoprotein NS . . . . . . . . . . . . . ............ Similarity of the NS Protein with Eukaryotic Transcription Activators . .. .. .. .. .. .. . .......... Roles of L and NS Proteins in Transcription ....................... References ......................................... V 99 100 101 104 109 117 119 122 vi CONTENTS Control of Expression and Cell Tropism of Human Immunodeficiency Virus v p e 1 JEROME A . ZACK. SALVATORE J . ARRIGO. AND IRVINS . Y . CHEN .........