E-Book Overview
Focusing on the latest breakthroughs in genetic analysis and manipulation, Genetic Models in Cardiorespiratory Biology extensively details how genetic model systems facilitate better comprehension of mammalian and human biology and disease. Highlights studies of Drosophila melanogaster, Caenorhabditis (C.) elegans, zebrafish, and transgenic mouse models-revealing high functional conservation to homologous genes in humans and promoting insight into biological processes! Applying technical and research advances toward the discovery of potential therapeutic gene agents, Genetic Models in Cardiorespiratory Biology ·summarizes current knowledge of cellular movements underlying heart tube morphogenesis and the role of genetic analysis in identifying critical molecules in cardiac development and formation ·illustrates the heterogeneity of tissue responses to hypoxia with genetic and invertebrate examples ·describes the control and influence of oxygen homeostasis by hypoxia-inducible factor-1 (HIF-1) on embryogenesis, physiology, and disease pathogenesis ·uses the Drosophila model to show the interface between global specification of cardiac competence and cell-type specific differentiation within the developing embryo ·studies over 40 mutations in zebrafish and mouse genes detailing vertebrate heart development, distinguishing novel genes in cardiac development, and delineating signaling pathways ·demonstrates the fundamental asymmetrical structure of the node monocilium through leftright asymmetry abnormalities ·considers the role and relationship of apoptosis in vertebrates and to the development of immune and cardiac systems, autoimmune and cardiac diseases, and cancer ·presents evolving paradigms in vasculogenesis and angiogenesis and the importance of the vascular endothelial growth factor (VEGF) family ·and much more! Written by nearly 25 experts in the field and supplemented with more than 1600 literature references, drawings, photographs, and tables, Genetic Models in Cardiorespiratory Biology satisfies the reference needs of pulmonologists and pulmonary disease specialists, geneticists, cardiologists, physiologists, biochemists, molecular and cell biologists, neonatologists and pediatricians, pathologists, anatomists, and graduate-level and medical school students in these disciplines.
E-Book Content
ISBN: 0-8247-0512-2 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-261-8482; fax: 41-61-261-8896 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2001 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA
To my wife Karen, my children Christopher, Diana, and Justin, my late father George and mother Aida, who always gave me support and encouragement GGH To my wife Wan, my children Helen, Heather, and Hannah, my parents Xu Xuejin and Li Jun, and my teachers Spyros Artavanis-Tsakonas and Gerry Rubin TX and to Vincent T. Marchesi and Joseph B. Warshaw, for their unrelenting efforts to bridge science to medicine, foster interaction across disciplines, and bring us together to address scientific questions of clinical importance
INTRODUCTION
During the 20th century, cardiovas