Alzheimer's Disease: Advances In Etiology, Pathogenesis And Therapeutics

Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad Copyright & 2001 John Wiley & Sons Ltd Alzheimer’s Disease ADVANCES IN ETIOLOGY, PATHOGENESIS AND THERAPEUTICS Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad Copyright & 2001 John Wiley & Sons Ltd This publication was supported by an educational grant from Janssen Pharmaceutica and Janssen Research Foundation Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad Copyright & 2001 John Wiley & Sons Ltd Alzheimer’s Disease ADVANCES IN ETIOLOGY, PATHOGENESIS AND THERAPEUTICS Edited by KHALID IQBAL New York State Institute for Basic Research, New York, USA SANGRAM S. SISODIA University of Chicago, Chicago, USA BENGT WINBLAD Karolinska Institute, Stockholm, Sweden JOHN WILEY & SONS, LTD Chichester . New York . Weinheim . Brisbane . Singapore . Toronto Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad Copyright & 2001 John Wiley & Sons Ltd Copyright & 2001 John Wiley & Sons Ltd. Baffins Lane, Chichester, West Sussex PO19 1UD, England National 01243 779777 International (+44) 1243 779777 e-mail (for orders and customer service enquiries): [email protected] Visit our Home Page on http://www.wiley.co.uk or http://www.wiley.com All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright Designs and Patents Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 9HE, UK, without the permission in writing of the Publisher Other Wiley Editorial Offices John Wiley & Sons, Inc., 605 Third Avenue, New York, NY 10158-0012, USA WILEY-VCH Verlag GmbH, Pappellallee 3, D-69469 Weinheim, Germany John Wiley & Sons Australia Ltd, 33 Park Road, Milton, Queensland 4064, Australia John Wiley & Sons (Asia) Pte Ltd, Clementi Loop #02-01, Jin Xing Distripark, Singapore 129809 John Wiley & Sons (Canada) Ltd, 22 Worcester Road, Rexdale, Ontario M9W 1L1, Canada Library of Congress Cataloging-in-Publication Data Alzheimer’s disease: advances in etiology, pathogenesis and therapeutics / edited by Khalid Iqbal, Sangram S. Sisodia, Bengt Winblad p. ; cm. Includes bibliographical references and index. ISBN 0-471-52176-0 (cased : alk. paper) 1. Alzheimer’s disease—Congresses. I. Iqbal, Khalid. II. Sisodia, Sangram S. III. Winblad, Bengt. IV. International Conference on Alzheimer’s Diseases and Related Disorders (7th : 2000 : Washington, D.C.) [DNLM: 1. Alzheimer Disease—etiology—Congresses. 2. Alzheimer Disease— pathology—Congresses. 3. Alzheimer Disease—therapy—Congresses. WT 155 A4757 2001] RC523 A3753 2001 616.8’31—dc21 00–067218 British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library ISBN 0-471-52176-0 Typeset from authors’ disks in 10 on 12 point Plantin by Dobbie Typesetting Limited, Tavistock, Devon Printed and bound in Great Britain by Biddles Ltd, Guildford and King’s Lynn This book is printed on acid-free paper responsibly manufactured from sustainable forestry, in which at least two trees are planted for each one used for paper production. Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Edited by Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad Copyright & 2001 John Wiley