Advances In Pharmacology And Chemotherapy Volume 17

ADVANCES IN Pharmacology and Chemotherapy VOLUME 17 ADVISORY BOARD D. BOVET Istituto Superiore de Sanita Rome, Italy B. B. BRODIE National Heart Institute Bethesda, Maryland J. H. BURN Oxford University Oxford, England A. CARLSSON Department of Pharmacology University of Goteborg Goteborg, Sweden K. K . CHEN Department of Pharmacology University of Indiana Indianapolis, Indiana J . F. DANIELLI , Worcester Polytechnic Institute Worcester, Massachusetts R. DOMENJOZ Pharmakologisches Institut Universitat Bonn Bonn, Germany B . N. HALPERN Dkpartement de Mkdecine Expe'rimentale CollPge de France Paris, France A. D. WELCH St. Jude Children's Research Hospital Memphis, Tennessee ADVANCES IN Pharmacology and Chemotherapy EDITED BY Silvio Garattini A. Goldin lstituto di Ricerche Farmacologiche “Mario Negri” Milano. Italy National Cancer Institute Bethesda, Maryland F. Hawking 1. J. Kopin Commonwealth Institute of Helminthology St. Albans, Herts., England National Institute of Mental Health Bethesda, Maryland Consulting Editor R. J. Schnitzer Mount Sinai School of Medicine New York, New York VOLUME 17- 1980 ACADEMIC PRESS A Subsidiary of Harcourt Brace Jovanovich, Publishers New York London Toronto Sydney San Francisco COPYRIGHT @ 1980, BY ACADEMIC PRESS,INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. 111 Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. ( L O N D O N ) LTD. 24/28 Oval Road, London N W l IDX LIBRARY OF CONGRESS CATALOG CARD NUMBER:61-18298 ISBN 0-12-032917-4 PRINTED IN THE UNITED STATES OF AMERICA 80 81 82 83 9 8 7 6 5 4 3 2 1 CONTENTS CONTRIBUTORS TO THISVOLUME . . . . . . . . . . . . . . . ix Screening for and Evaluation of Anticoccidial Activity JOHNF. RYLEY I. Introduction . . . . . . . . 11. Screening in Embryos or Tissue Culture 111. Screening in the Chicken. . . . . IV. Cage Evaluation Experiments . . . V. Drug Resistance Studies . . . . . VI. Point and Type of Action Studies . . VII. Conclusions . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 10 I8 19 20 21 22 Information Services of the International Cancer Research Data Bank (ICRDB) Program in Cancer Chemotherapy and Pharmacology JOHNH. SCHNEIDER I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. Collection of Data . . . . . . . 111. ICRDB Data Bases for Cancer Researchers . . . . . . . . . 25 26 29 IV. Searching of Cancer Data Bases and Indexing of Biomedical Information . . . . . . . . . . . . . . . . . . . 30 V. Publications Used to Disseminate Cancer-Related Information Automatically . . . . . . . . . . . . . . . VI. Scientist-to-Scientist Communication Projects . . . . . Reference . . . . . . . . . . . . . . . . . 32 34 35 . . . . . . . . . . . Dihydrofolate Reductase: Binding of Substrates and Inhibitors and Catalytic Mechanism JILLE. GREADY I. Introduction . . . . . . . . 11. Critical Aspects of the Enzyme Structure V . . . . . . . . . . . 37 . . . . . . . . . . . 41 vi CON