ADVANCESINCANCER RESEARCH VOLUME 36 Contributors to This Volume Gianni Bonadonna Philip D. Lipetz Clark M. Edson Janet D. Rowley Maria E. Ferioli Armando Santoro Steinar Funderud Giuseppe Scalabrino Alan G. Galsky Ralph E. Stephens Kathi Geilinger Joseph R. Testa Tore Godal David A. Thorley-Lawson Robert A. Weinberg ADVANCES IN CANCER RESEARCH Edited by GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden SIDNEY WE INHOUSE Fels Research Institute Temple University School of Medicine Philadelphia, Pennsylvania Volume 36-1982 ACADEMIC PRESS A Subsidiary of Harcourt Brace Jovanovich, Publishers New York London Paris San Diego San Francisco SBo Paul0 Sydney Tokyo Toronto COPYRIGHT @ 1982, BY ACADEMIC PRESS,INC. ALL RIGHTS RESERVED. NO PART O F THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMlSSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS,INC. 1 I1 Fifth Avenue, New York, New York 10003 United Kirigdoni Edition published by ACADEMIC PRESS, INC. ( L O N D O N ) LTD. 24/28 Oval Road, London N W I 7DX LIBRARY OF CONGRESS CATALOG CARDNUMBER: 52-13360 ISBN 0-12-006636-X PRINTED IN THE UNlTED STATES OF AMERICA 82 83 64 85 9 8 7 6 5 4 3 2 1 CONTENTS CONTRlBUTORSTOVOLUME36 . . . . ix Polyamines in Mammalian Tumors: Part II GIUSEPPESCALABRINO AND MARIAE . FERIOLI I . Polyamine Biosynthesis and Concentrations in Different Lines of Cultured Neoplastic Cells . . . . . . . . . . . . . . . . . . . . I1. Polyamines in Human Oncology . . . . . . . . . . . . . . . . . . . . . 111. Diamine Oxidase Activity in Human and in Experimental Neoplasms . . . . . IV . Physiological and Pharmacological Inhibitors of Polyamine Biosynthesis in Neoplastic Tissues or Cells . . . . . . . . . . . . . . . . . V. Concluding Remarks and Speculations . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 20 56 62 86 88 Chromosome Abnormalities in Malignant Hematologic Diseases JANET D . ROWLEYA N D JOSEPH R . TESTA I . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . Methods . . . . . . . . . . . . . . . . . . . . . . . . . . Chronic Myelogenous Leukemia (CML) . . . . . . . . . . . . . Acute Nonlymphocytic Leukemia (ANLL) . . . . . . . . . . . . Acute Lymphocytic Leukemia (ALL) . . . . . . . . . . . . . . Polycythemia Vera . . . . . . . . . . . . . . . . . . . . . . Implications of Nonrandom Changes for Malignant Transformation . References . . . . . . . . . . . . . . . . . . . . . . . . . I1. I11. IV . V. VI . VII . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 105 107 116 126 132 . . . . . 139 . . . . . 143 Oncogenes of Spontaneous and Chemically Induced Tumors ROBERTA . WEINBERG I . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . I1. A Model of Cellular Oncogenes . . . . . . . . . . . . . . . . . I11. The Retrovirus-Associated Oncogenes . . . . . . . . . . . . . . IV . Oncogenes Present in Cells Transformed by Chemical Carcinogens . . . . . . . . 149 . . . 150 . . . . 150 . . . . 153 V . Multiplicity of Transforming Genes in 3-Methylcholanthrene-Transformed Cells 155 VI . Types ofTransformed Cells Yielding Focus-Induced DNA . . . . . . . . . . 156 V vi CONTENTS VII . Multiplicity of Different Human Oncogenes . . . . . . . . . . . . . . . . VIII . Analogies between Virus- and Non-Virus-Indu