E-Book Overview
Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.
E-Book Content
Annual Reports in
Combinatorial Chemistry and
Molecular Diversity Volume 1
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Annual Reports in
Combinatorial Chemistry and
Molecular Diversity Volume 1 edited by
W.H. Moos MitoKor San Diego, CA 92121 , U.S.A.
M.R. Pavia Sphinx Pharmaceuticals Cambridge, MA 02139, U.S.A.
B.K. Kay University of North Carolina Chapel Hill, NC 27599-3280, U.S.A.
A.D. Ellington Indiana University Bloomington, IN 47405, U.S.A.
KUWER ACADEMIC PUBLISHERS New York / Boston / Dordrecht / London / Moscow
eBook ISBN: Print ISBN:
0-306-46904-9 9-072-19923-5
©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©1997 ESCOM Science Publishers B.V. Leiden All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's eBookstore at:
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Preface Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product research and development (R&D) have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery – better, faster, cheaper! Notably, more compounds have been made and screened in the 1990s than in the last 100 years of pharmaceutical research combined, and new drug candidates are possibly for the first time making their way into clinical development pipelines in a more efficient way. After leading the way in 1995–1996 with the first scientific journal to represent this new field and discipline, ESCOM leads the way again with ‘Annual Reports in Combinatorial Chemistry and Molecular Diversity’ (ARCCMD). Just as ‘Annual Reports in Medicinal Chemistry’ (Academic Press) has established a premier position for yearly reviews in pharmaceutical chemistry and related topics, ARCCMD will do the same for the burgeoning new arena of combinatorial chemistry and molecular diversity. This annual is a ‘must read’ for everyone involved in pharmaceutical and biotechnology R&D, and also for those who are training students for careers in the industry. Moreover, as the field of molecular diversity expands into areas such as bio-organic chemistry, materials science, and beyond, the series will be of consider