ADVANCES IN CANCER RESEARCH Volume III This Page Intentionally Left Blank ADVA-NCES IN CANCER RESEARCH EDITED BY JESSE P. GREENSTEIN NationaE Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland ALEXANDER HADDOW Chester Beatty Research Institute, Royal Cancer Hospital, London, England Volume 1 I I ACADEMIC PRESS INC., PUBLISHEHS NEW YORK, N.Y. 1955 COPYRIGHT 1955, BY ACADEMIC PRESS INC. 125 East 23rd Street, New York 10, N.Y. All Rights Reserved No part of this book may be reproduced in any form, by photostat, microfilm, or any other means without written permission from the publishers. Library of Congress Catalog Card Number: 52-13360 PRINTED IN THE UNITED STATES OF AMERICA CONTRIBUTORS TO VOLUME I11 RICHARD DOLL,Statistical Research ['?zit, The Medical Research Council, London School of Hygiene and Tropical Medicine, London, England HAROLD P. MORRIS, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland A. PULLMAX, Institut du Radium, Paris, France R. PULLMAX, Institut d u Radium, Paris, France P. ROSDONI,Cancer Institute, Milan, Italy MICHAEL B. SHIMKIN, National Cancer Institute, National Institutes of Health, Bethesda, Maryland SIDNEY WEINHOUSE,The Lankenau Hospital Research Institute and The Instal iite jor Cancer Research, Philadelphia, Pennsylcania This Page Intentionally Left Blank CONTENTS CONTRIBUTORS TO VOLUME 111. . . . . . . . . . . . . . . . . . . . . . v Etiology of Lung Cancer BY RICHARD DOLL.Statistical Research Crnit. The Medical Research Council. London S c h l of Hygiene and Tropical Medicine. London. England 1. Introdurtion . . . . . I1. Increase in Incidence . I11. Etiological Factors . . IV . Conclusion . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 8 46 47 The Experimental Development and Metabolism of Thyroid Gland Tumors BYHAROLD P . MORRIS.IAhoratory of Biochemistry. National Cancer Institute. National Institutes of Health. Belhesda. Maryland I . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . I1. Thyroid Gland Biochemistry and Metabolism . . . . . . . . . . . . . I11. Spontaneous Thyroid Tumors . . . . . . . . . . . . . . . . . . . . I V . Effect of Goitrogens and Iodine on Body Weight. and Thyroid Weight . . . V . Induction of Thyroid Gland Cancer by Chemical Carcinogens . . . . . . V I . Dietary Iodine Deficiency and Experimental Development of Thyroid Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VII . Goitrogen-Induced Thyroid Gland Tumors in hlice . . . . . . . . . . VIII . Transplantability of Thyroid Gland Tumors in Mice . . . . . . . . . . IX. Thyroid-Pituitary Interrelationships . . . . . . . . . . . . . . . . . X . Effects of Ionizing Rndintions in Thyroid Gland Carcinogenesis . . . . . XI . Experiment.al Thyroid Tumors in Rats Produced by Goitrogens and Carcinogem . . . . . . . . . . . . . . . . . . . . . . . . . . . . XI1. Transplantability and Xlrtnbolism of R a t Thyroid Gland Tumors . . . . XI11. Biochemistry of Thyroid Gland Tumors in Mice . . . . . . . . . . . XIV . Thyroid Gland Cancer in %Ian . . . . . . . . . . . . . . . . . . . XV . Summary nnd Conclusions . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 53 56 58 60 GO 62 62 65 68 75 81 80 102