ADVANCES I N CANCER RESEARCH VOLUME 10 Contributors to This Volume J. M. Barnes J. S. Harington Daniel E. Bergsagel A. Haut H. V. W. Eugene Knox Gelboin A. Clark Griffin P. N. Magee K. M. Griffith W. J. Stuckey, Jr. ADVANCES IN CANCER RESEARCH Edited by ALEXANDER HADDOW Chester Beatty Research Institute Institute of Cancer Research Royal Cancer Hospital, London, England SIDNEY WEINHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania Volume 70 @ ACADEMIC PRESS 1967 NEW YORK AND LONDON COPYRIGHT @ 1967, BY ACADEMIC PRESS INC. ALL RIGHTS RESERVED. NO PART OF T H I S BOOK MAY BE REPRODUCED I N ANY FORM, BY PHOTOSTAT, MICROFILM, OR ANY OTHER MEANS, WITIIOCIT WRITTEN PERMISSION FROM T H E PUBLISHERS. ACADEMIC PRESS INC. 111 Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) LTD. Berkeley Square House, London W . l LIBRARY O F CONGRESS CATALOG CARD NUMBER: 52-13360 PRINTED I N T H E UNITED STATES OF AMERICA CONTRIBUTORS TO VOLUME 10 Numbers in parentheses rcfer to the pages on which the authors’ contributions begin. J. M. BARNES, Toxicology Research Unit, Medical Research Council Laboratories, Carshalton, Surrey, England (163) DAKIEL E. BERGSAGEL,* University of Texas M . I). Anderson Hospital and Tumor Institute, Houston, Texas (311) H. V. GELBOIN,National Cancer Institute, National Institutes of Health, Departrnent of Health, Education and Welfare, Bethesda, Maryland (1) A. CLARK GRIFFIN,T h e University of Texas M . D . Anderson Hospital and Tumor Institute, Houston, Texas (83) K. M. GRIFFITH,Department of Biomathematics, University of Texas M . D . Anderson Hospital and Tumor Institute, Houston, Texas (311) J. S.HARINGTON,? Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, England (247) A. HAW, University of ilrkarisas School of Medicine, Little Rock, Arkansas (311) W. EUGENE KNOX,Department of Biological Chemistry, Harvard Medical School and the Cancer Research Institute, N e w England Deaconess Hospital, Boston, Massachusetts (117) P. N. MAGEE,Toxicology Research Unit, Medical Research Council Laboratories, Carshalton, Surrey, England (163) \V. ,J. STUCICEY, JR.,Tulane lrniversit y School of Medicine, N e w Orleans, LOU~S~U (311) WL * Present, Address: t PreserLl Princess Margaret Hospital, Toronto, Ontario, Canada. Atlclress: Canwr Rcsearch Unit of the National Cancer Association of South Africa, South African Institute for Medicaal Research, P. 0. Box 1038 Johannesburg, South Africa. V This Page Intentionally Left Blank CONTENTS CONTHIBUTORS T O VOLU\lE 10 . CONTENTS OF PRIWIOUS Vor.u\ifi>s . . V . . ix . . . 1 5 23 26 28 29 Carcinogens. Enzyme Induction. and Gene Action H . V . GBLBOIN I . Introduction . . . . . . . . . . . . . I1. Polycyclic Hydrocarbons and Enzyme Induction . . . . . I11. Tlie Effect of Drugs and Insecticides on Liver Microsomal Enzymes . IF’. The Nature of the Microsomal Drug-Metabolizing Enzyme Systems . . . . . . V . Effect o f Oncogrnic Viruses on Enzyme Intlnction V I . Enzyme Induction in Rat Hepatoma . . . . . . . . . VII . Pharmacological and Physiological Significance of Polycyclic Hydro. . . . . carbons and Drug-Induced Enzyme Activity . VIII . The Mechanism of Polycyclic Hydrocarbon and Drug-Induced Increase . . . .