Volume 144 Number 1 January 7, 2011 www.cell.com Presenilin Carves Neural Circuits Chromatin and Alternative Splicing Your bacteria's favorite! Eppendorf Eporator ® The Eppendorf Eporator: the solution for efficiently transforming bacteria and yeast! The Eppendorf Eporator is the perfect fit for you and your lab. Ask the specialists—your bacteria and yeast—they will confirm that the product features and performance of the Eppendorf Eporator make it very easy for you to carry out your experiments and obtain excellent results. Unique features of the Eppendorf Eporator Easy one-button start l Intuitive use guided by color display l Fast and freely programmable function keys l Integrated electroporation chamber for safety l Compact, space-saving design l USB port for data export l For more information visit www.eppendorfna.com/eporator www.eppendorf.com Þ Email:
[email protected] In the U.S.: Eppendorf North America, Inc. 800-645-3050 Þ In Canada: Eppendorf Canada Ltd. 800-263-8715 015.A1.0103.A © 2011 Eppendorf AG NEW! . W E N Intelligent design inCuSaFe™ copper enriched stainless steel interior + + Single-beam, dual capture infrared CO2 sensor + SafeCell UV protection in situ + 1 Hydrogen peroxide vapor sterilization in situ Good laboratory technique Sterisonic™ GxP Performance and Productivity Delivers Best Efficiency Value: 2 Hours SANYO Sterisonic™ 14 Hours Brand X H2O2 sterilization vs. high heat sterilization = Uptime (Hours) = Downtime (Hours) 7KH UDSLG in situ + 2 VHTXHQFH UHWXUQV WKH IXOO\ VWHULOL]HG 6WHULVRQLF *[3 WR QRUPDO XVH TXLFNHU WKDQ DQ\ FRPSHWLWLYH LQFXEDWRU LQ WKH ZRUOG The industry’s first in situ H2O2 sterilization with the fastest turnaround. For maximum productivity in clinical, general purpose or the most highly compliant GMP applications, the new SANYO Sterisonic™ GxP CO2 incubator offers an impressive return on investment. With multiple contamination control safeguards, exclusive on-board H2O2 sterilization, FDA-21CFR data capture and graphical LCD display, the Sterisonic™ GxP rewards good laboratory technique with performance ww.steriso onic.com or call 800-858-8442. you can trust. Learn more, visit ww pictured above: Sterisonic™ GxP MCO-19AICUVH with rapid H2O2 vapor sterilization system. FREEER OFF [ D E TA IL ! E S O N L IN ] FREE! FREE! H2O2 sterilization system acessory, plus BD labware consumables kit. Limited time upgrade offer with purchase of the Sterisonic™ GxP MCO 19AICUVH. ($900 Value) BD stem cell starter kit with Sterisonic™ GxP quote. No purchase necessary! Act now. Supplies are limited. ($150 Value) www.sterisonic.com ©2009 Sanyo Biomedical OWS 1015 05/09 Supplying Reagent, Pre-clinical and cGMP Grade Proteins to the Biopharmaceutical and Vaccine Development Community Recombinant Vaccine Components ! ! P. aeruginosa rEPA ! ! E. coli • C. difficile COMING SOON! • Circumsporozoite Protein Reagent Proteins is now your single source for reagent, pre-clinical and cGMP grade proteins. See our new website for a complete listing of products and special discounts of up to 30% on recombinant human proteins. Win an iPad ! Make a purchase by Feb 28, 2011 for a chance to win an iPad! Editor Emilie Marcus Senior Deputy Editor Elena Porro Deputy Editors Robert Kruger Connie M. Lee Scientific Editors Karen Carniol Kara Cerveny Michaeleen Doucleff Fabiola Rivas Niki Scaplehorn Lara Szewczak Senior Managing Editor Meredith Adinolfi Deputy Mana