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"...Discusses how the technique works and how to interpret results. ...Describes the impact of [LC-MS] on small-molecule and biomolecular applications...- Biophotonics International, August 2006Featuring new chapters and extensive revisions throughout the book, this book explains how to use LC-MS and interpret data for various disciplines. Placing a stronger emphasis on applications than previous editions, this edition also dedicates more than two-thirds of the text to examining new developments of LC-MS in emerging application areas, including environmental, food-safety, and clinical analysis as well as proteomics, pharmaceutical drug discovery and natural products research. Each chapter examines how recent advances strategies, and technologies shaped each of these disciplines, supported by most relevant literature available.
E-Book Content
DK2272_half-series-title.qxd 6/22/06 1:13 PM Page i Liquid Chromatography– Mass Spectrometry Third Edition Wilfried M.A. Niessen hyphen MassSpec Consultancy Leiden, The Netherlands © 2006 by Taylor and Francis Group, LLC CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2006 by Taylor and Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8247-4082-3 (Hardcover) International Standard Book Number-13: 978-0-8247-4082-5 (Hardcover) Library of Congress Card Number 2006013709 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data a