E-Book Overview
This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain. Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.
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Blood-Brain Barriers Edited by Rolf Dermietzel, David C.Spray, Maiken Nedergaard Blood-Brain Interfaces: From Ontogeny to Artificial Barriers. Edited by R. Dermietzel, D. C. Spray, M. Nedergaard Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 3-527-31088-6 Related Titles R. A. Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine T. A. Woolsey, J.Hanaway, M. H. Gado The Brain Atlas 2nd Edition A Visual Guide to the Human Central Nervous System 2005. ISBN 3-527-30542-4 2002. ISBN 0-471-43058-7 O. von Bohlen und Halbach, R. Dermietzel S. H. Koslow, S. Subramaniam (Eds.) Neurotransmitters and Neuromodulators Handbook of Receptors and Biological Effects 2nd Edition 2006. ISBN 3-527-31307-9 G. Thiel (Ed.) Transcription Factors in the Nervous System Development, Brain Function, and Diseases 2006. ISBN 3-527-31285-4 Databasing the Brain: From Data to Knowledge (Neuroinformatics) 2005. ISBN 0-471-30921-4 C. U. M. Smith Elements of Molecular Neurobiology 2002. ISBN 0-470-84353-5 R. Webster (Ed.) Neurotransmitters, Drugs and Brain Function 2001. ISBN 0-471-97819-1 M. Bähr (Ed.) Neuroprotection Models, Mechanisms and Therapies 2004. ISBN 3-527-30816-4 S. Frings, J. Bradley (Eds.) Transduction Channels in Sensory Cells 2004. ISBN 3-527-30836-9 Blood-Brain Barriers From Ontogeny to Artificial Interfaces Volume 1 Edited by Rolf Dermietzel, David C.Spray, Maiken Nedergaard Editors: Prof. Dr. Rolf Dermietzel Department of Neuroanatomy and Molecular Brain Research Ruhr University Bochum Universitätsstrasse 150 44780 Bochum Germany Prof. Dr. David Spray Department of Neuroscience Albert Einstein College of Medicine 1410 Pelham Parkway S Bronx, NY 10464 USA Prof. Dr. Maiken Nedergaard School of Medicine and Dentistry University of Rochester 601 Elmwood Avenue Rochester, NY 14642 USA n All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate. Library of Congress Card No.: applied for British Library Cataloguing-in-Publication Data: A catalogue record for this book is available from the British Library Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is avai