Principles of Nucleic Acid Structure This page intentionally left blank Principles of Nucleic Acid Structure Stephen Neidle The School of Pharmacy University of London, London, UK AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 84 Theobald’s Road, London WC1X 8RR, UK Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2008 Copyright © 2008 Elsevier Inc. All rights reserved Material in this book originally published in “Nucleic Acid Structure and Recognition”, by Stephen Neidle (Oxford University Press, 2002) No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email:
[email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made CIP applied for and in process ISBN: 978-0-12-369507-9 For information on all Academic Press publications visit our website at books.elsevier.com Printed and bound in USA 08 09 10 11 12 10 9 8 7 6 5 4 3 2 1 On the Cover: Structure of the nucleosome core particle, drawn from coordinates taken from PDB entry no. 1KX3 (Davey et al., Solvent mediated interactions in the structre of the nucleosome core particle at 1.9 Å resolution. J. Mol. Biol. 2002, 319, 1097–1113