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Volume 438 Number 7065 pp129-256 In this issue (10 November 2005) • • • • • • Editorials Research Highlights News News Features Business Correspondence Also this week • Autumn Books • News and Views • Brief Communications Brief Communications Arising (this content only available online) • Articles • Letters • Naturejobs • Futures • Editor's Summary • Authors • Nature Podcast Editorials DARPA dreaming p129 Replicating the success of the US Defense Advanced Research Projects Agency (DARPA), in an organization devoted to energy research, will be easier said than done. A less toxic solution p129 Industry should get behind a European partnership that will explore alternatives to animal testing. Flu in circulation p130 An interim US rule on safeguards may not, on its own, be enough to contain the 1918 flu virus. Research Highlights Research highlights p132 News Deadly flu virus can be sent through the mail p134 US lab agrees to share reconstructed pandemic strain. Andreas von Bubnoff Far East lays plans to be stem-cell hotspot p135 Asia seeks to capitalize on home-grown expertise. David Cyranoski Sidelines p136 Researchers break the rules in frustration at review boards p136 Experiments on human subjects go ahead without official approval, says survey. Jim Giles Boeing strike leaves satellites stranded on launch pad p137 Rocket mechanics down tools over healthcare dispute. Geoff Brumfiel Antigravity craft slips past patent officers p139 'Impossible' device gets seal of approval. Philip Ball Bush buries US bunker-buster project p139 Plans for ground-penetrating nuclear warhead scrapped. Geoff Brumfiel Congress attacked over species bill p140 Conservationists rally in face of law reforms. Rex Dalton News in brief p142 News Features Animal testing: More than a cosmetic change p144 Commercial and political pressures are pushing for a halt to the use of animals in toxicology tests