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Vol 431 No 7008 pp491-612 Editorials News News Feature Correspondence Commentary Books and Arts Essay News and Views Brief Communications Articles Letters to Nature Technology Feature Naturejobs 30 September 2004 Editorials Holding the line at NASA 491 Space-based astronomy in the United States is under threat thanks to a misplaced sense of priorities within government. Researchers should take every opportunity to resist and to make the most of support from Congress. Open-source biology 491 Researchers and entrepreneurs alike should welcome a move to develop a new commons in technological innovation. News Global AIDS trial denied patients as US balks at generic drug use 493 Tests of antiretrovirals stalled. Biologists launch 'open-source movement' 494 Research tools and technologies to be made freely available. Support sought to investigate sluggish Pioneers 494 Physicists study mystery of slow-moving spacecraft. Monkey virus may be cleared of cancer link 495 Plasmid contamination may exonerate virus. Ancient ships lifted from Naples' railway tunnels 496 Construction workers stumble on archaeological treasure. Feathers fly as China cracks down on illegal fossil sales 496 Valuable dinosaur fossil may have been crushed in fracas. Beagle cash dogged by dissent over wording 497 Does Britain owe 16 million for Mars mission 'loan'? NIH researchers face blanket consulting ban 497 Plans in place to stop scientists taking extra paid work. news in brief 498 News Feature Hormone therapy: A dangerous elixir? 500 Testosterone therapy jacks up vigour, sex drive and mental acuity — or so proponents claim. But are those who experiment with this potent sex hormone gambling with their health? Helen Pearson investigates. Aquaculture: Fishing for trouble 502 Plans to push tuna farms out into open waters off the coast of the United States are raising an environmental alarm. Rex Dalton discovers the kind of pr