E-Book Overview
In an unprecedented integration of cutting-edge ideas in immunology with clinical neuropathological findings, Neuroinflammation: Mechanisms and Management reviews and synthesizes our knowledge of the inflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of the role of biochemical mediators in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine research on the design of specific pharmacological agents to inhibit defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and therapeutic actions of first generation agents, as well as their potential clinical relevance to AIDS dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.
E-Book Content
NEUROINFLAMMATION Mechanisms and Management SECOND EDITION Edited by PAUL L. WOOD HUMANA PRESS NEUROINFLAMMATION Contemporary Neuroscience Neuroinflammation: Mechanisms and Management, Second Edition, edited by Paul L. Wood, 2003 Neurobiology of Aggression: Understanding and Preventing Violence, edited by Mark P. Mattson, 2003 Neural Stem Cells for Brain and Spinal Cord Repair, edited by Tanja Zigova, Evan Y. Snyder, and Paul R. Sanberg, 2003 Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition, edited by Maarten E. A. Reith, 2002 The Neuronal Environment: Brain Homeostasis in Health and Disease, edited by Wolfgang Walz, 2002 Pathogenesis of Neurodegenerative Disorders, edited by Mark P. Mattson, 2001 Stem Cells and CNS Development, edited by Mahendra S. Rao, 2001 Neurobiology of Spinal Cord Injury, edited by Robert G. Kalb and Stephen M. Strittmatter, 2000 Cerebral Signal Transduction: From First to Fourth Messengers, edited by Maarten E. A