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Ever since their discovery, adenoviruses have proven to be tremendousasset to biologists. Through the study of the adenoviruses theauthors have learned not only about the virus structures, mechanismsof viral replication, but also about eukaryotic gene expression,alternative splicing, regulation of cell cycle progression, andapoptosis. In the last five years, there has been an explosion in the use of adenoviruses as vectors for gene transfer to a variety of mammalian cells. Adenoviral vectors are also being tested in Phase I clinical trials for cystic fibrosis and for many kinds of cancers. These recent developments in utilizing adenoviral vectors for gene therapy have rejuvenate an interest in the basic science of adenovirus research. More importantly, it has generated a necessity for a single volume that covers both the biology of adenoviruses aswell as our progress in the use of adenoviruses as vectors for gene therapy. This book was written precisely to fulfill such a need.
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MEDICAL INTELLIGENCE UNIT 15 Prem Seth Adenoviruses: Basic Biology to Gene Therapy R.G. LANDES C OM PA N Y MEDICAL INTELLIGENCE UNIT 15 Adenoviruses: Basic Biology to Gene Therapy Prem Seth, Ph.D. Human Gene Therapy Research Institute Des Moines, Iowa, U.S.A. and Medicine Branch National Cancer Institute National Institutes of Health Bethesda, Maryland, U.S.A. R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A. MEDICAL INTELLIGENCE UNIT Adenoviruses: Basic Biology to Gene Therapy R.G. LANDES COMPANY Austin, Texas, U.S.A. Copyright ©1999 R.G. Landes Company All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the