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This widely used text is now fully updated to reflect the broad acceptance and availability of PET, including instrumentation and special radiation safety aspects. Also added are new information on radiopharmaceuticals, newer scintillation materials (BGO), fusion imaging (PET/CT and SPECT/CT), descriptions of SPECT filters, discussions on contrast detail curves, and radiation effects on cell culture. An easy-to-read format and eye-friendly internal design facilitate learning and guide readers through essential details, examples, and true-to-life problems. A testing component at the end of each chapter offers key points for review with questions and answers.
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Nuclear Medicine Physics The Basics 6th Edition 2004 Lippincott Williams & Wilkins Philadelphia 530 Walnut Street, Philadelphia, PA 19106 USA 978-0-7817-4753-0 0-7817-4753-8 Acquisitions Editor: Lisa McAllister Developmental Editor: Kathryn Stadel Production Editor: Jeffrey Somers Manufacturing Manager: Colin Warnock Cover Designer: Karen Quigley Compositor: TechBooks Printer: Maple-Press © 2004 by LIPPINCOTT WILLIAMS & WILKINS 530 Walnut Street Philadelphia, PA 19106 USA LWW.com All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. Printed in the USA Fifth Edition, 1998 Library of Congress Cataloging-in-Publication Data Chandra, Ramesh, 1938Nuclear medicine physics: the basics/Ramesh Chandra.—6th ed. p. ; cm. Includes bibliographical references and index. ISBN 0-7817-4753-8 (pbk.) 1. Medical physics. 2. Nuclear medicine. 3. Radioisotopes. I. Title. [DNLM: 1. Health physics. 2. Nuclear medicine. 3. Radioisotopes. WN 110 C457n 2004] R895.C47 2004 616.07′575—dc22 2002043075 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. 10 9 8 7 6 5 4 3 2 1 iv Dedication To my wife, Mithilesh, my son, Anurag, and my daughter, Ritu v AUTHORS Ramesh Chandra PhD Professor Department of Radiology New York University Medical Center New York, New York vi Preface The purpo