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New Chemistry and New Opportunities from the Expanding Protein Universe July 25, 2013 17:28 WSPC - Proceedings Trim Size: 9.75in x 6.5in This page intentionally left blank icmp12-master 23rd International Solvay Conference on Chemistry New Chemistry and New Opportunities from the Expanding Protein Universe Hotel Métropole, Brussels 16 – 19 October 2013 Scientific Editors Kurt Wüthrich The Scripps Research Institute, USA & ETH Zürich, Switzerland Ian A. Wilson The Scripps Research Institute, USA Donald Hilvert ETH Zürich, Switzerland Dennis W. Wolan The Scripps Research Institute, USA International Solvay Institutes Editor Anne De Wit Université Libre de Bruxelles, Belgium World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TA I P E I • CHENNAI Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE Library of Congress Cataloging-in-Publication Data International Solvay Conference on Chemistry (23rd : 2013 : Brussels, Belgium) New chemistry and new opportunities from the expanding protein universe : proceedings of the 23rd International Solvay Conference on Chemistry, Hotel Métropole, Brussels 16–19 October 2013 / editor, Kurt Wüthrich, The Scripps Research Institute, USA & ETH Zürich, Switzerl [and 4 others]. pages cm Includes bibliographical references and index. ISBN 978-9814603829 (hardcover : alk. paper) -- ISBN 9814603821 (hardcover : alk. paper) -- ISBN 978-9814616560 (pbk. : alk. paper) -- ISBN 9814616567 (pbk. : alk. paper) 1. Proteins--Synthesis--Congresses. 2. Enzymes--Congresses. I. Wüthrich, Kurt, editor. II. Title. QP551.I5188 2013 612'.01575--dc23 2014024092 British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Copyright © 2014 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the publisher. For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. Printed in Singapore October 14, 2014 14:31 WSPC Proceedings - 9.75in x 6.5in master/pg v v Contents I. The International Solvay Institutes II. III. Solvay Scientific Committee for Chemistry Acknowledgements IV. V. Participants Auditors VI. Opening Address by Professor M. Henneaux VII. Preface by Professor K. W¨ uthrich xi xiii xv xvi xviii xix xxi Session 1: New Chemistry in the Expanding Protein Universe 1 1.1 Novel Chemistry Still to be Found in Nature C. T. Walsh 3 1.2 Natural Product Biosynthesis in the Genomic Age W. A. van der Donk 6 1.3 Peptide Dendrimers and Polycyclic Peptides J.-L. Reymond 1.4 What can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution? N. L. Dawson, R. Studer, N. Furnham, D. Lees, S. Das, J. Thornton and C. Orengo 11 16 1.5 Exploring Chromatin Biology Using Protein Chemistry T. W. Muir <