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Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood vessel diseases as seen in diabetes and atherosclerosis, on the altered immune surveillance that leads to autoimmunity and on the fundamental mechanisms by which growth factors signal their target cells. We expect that the contents of this volume will help promote understanding of the role of these fundamental biological processes and their alterations in a wide variety of disease states and stimulate new investi gations in this important area of biomedical research. The Editors v CONTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived Growth Factor- Its Role in Health and Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 R. Ross and E. W. Raines Molecular and Developmental Biology Aspects of Fibroblast Growth Factor. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical Properties of Human Angiogenin. . . . . . . . . . 41 B. L. Vallee and J. F. Riordan GROWTH FACTOR - ONCOGENE RELATIONSHIPS Structure - Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . 55 T. Pawson. P. Greer, M. Moran, K.
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BIOLOGY OF GROWTH FACTORS Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 226 MOLECULAR MECHANISM OF MUSCLE CONTRACTION Edited by Haruo Sugi and Gerald H. Pollack Volume 227 OXYGEN TRANSFER FROM ATMOSPHERE TO TISSUES Edited by Norberto C. Gonzalez and M. Roger Fedde Volume 228 THE MOLECULAR IMMUNOLOGY OF COMPLEX CARBOHYDRATES Edited by Albert M. Wu and L. Garry Adams Volume 229 LIPOXINS: Biosynthesis, Chemistry, and Biological Activities Edited by Patrick Y-K Wong and Charles N. Serhan Volume 230 CELL AND MOLECULAR BIOLOGY OF THE UTERUS Edited by Wendell W. Leavitt Volume 231 ADVANCES IN POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS AND AGING Edited by Vincenzo Zappia, Patrizia Galletti, Raffaele Porta, and Finn Wold Volume 232 CELLULAR Cal+ REGULATION Edited by Douglas R. Pfeiffer, Jeanie B. McMillin, and Steve Little Volume 233 CANCER METASTASIS Edited by Giorgio Prodi, Lance A. Liotta, Pier-Luigi Lollini, Spiridione Garbisa, Sergio Gorini, and Kurt Hellmann Volume 234 BIOLOGY OF GROWTH FACTORS: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications Edited by Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, and A vrum I. Gotlieb A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. BIOLOGY OF GROWTH FACTORS Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications Edited by Jeffrey E. Kudlo