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BIOLOGY OF RADIOIODINE Proceedings of the Hanf or d Symposium on the Biology of Radioiodine Sponsored by THE U.S. ATOMIC ENERGY COMMISSION and the HANFORD LABORATORIES OF THE GENERAL ELECTRIC COMPANY RICHLAND, WASHINGTON, JULY 17-19 Edited by L. K. BUSTAD SYMPOSIUM PUBLICATIONS DIVISION PERGAMON PRESS OXFORD · LONDON · EDINBURGH · NEW YORK PARIS · FRANKFURT 1964 PERGAMON PRESS LTD. Headington Hill Hall, Oxford 4 and 5 Fitzroy Square, London W.l P E R G A M O N PRESS (SCOTLAND) LTD. 2 and 3 Teviot Place, Edinburgh 1 PERGAMON PRESS INC. 122 East 55th Street, New York 22, N.Y. G A U T H I E R - V I L L A R S ED. 55 Quai des Grands Augustins, Paris, 6 PERGAMON PRESS G.m.b.H. Kaiserstrasse, 75 Frankfurt am Main Distributed in the Western Hemisphere by THE MACMILLAN COMPANY · NEW YORK pursuant to special arrangement with Pergamon Press Limited Copyright © 1964 PERGAMON PRESS L T D . Library of Congress Catalogue Card Number 64-15928 This collection of papers has recently been published in the Journal of Health Physics Vol. 9, No. 12 {Pergamon Press 1963) Printed in Great Britain by The Universities Press, Belfast, Northern Ireland INTRODUCTION H. A. K O R N B E R G contributions in the area of the subject matter of this symposium he was appointed its Honorary Chairman. T h e first in this series of symposia was o n the I N A sense this second Hanford symposium h a d its beginning fifteen years ago when we set o u t Biology of the T r a n s u r a n i u m Elements a n d was to evaluate the hazard to animals grazing on held here one year ago. Its general chairman land contaminated with radioactive contami was D r . R O Y C. THOMPSON, a n d proceedings of nants from airborne production wastes. Plans the symposium were published in the December were m a d e in 1948 for the now well-known 1962 issue of Health Physics. Next year's Sympo experiment on t h e toxicity of I 1 3 1 in large sium will be on the Biology of Radioactive animals. T o help perform t h e experiments D r . Particles, under the general chairmanship of Biology Laboratory, Hanford Laboratories, General Electric Company, Richland, Washington L E O BUSTAD was added to our almost non existent staff in biology. Since then his contribu tions to knowledge of the biological effects of I 1 3 1 have been many, a n d it is appropriate that he is the General C h a i r m a n of the second Hanford Biology Symposium. While our I 1 3 1 toxicity experiment was still in its planning stages D r . SHIELDS W A R R E N kindly extended a n invitation to D r . BUSTAD to spend some time studying radiation pathology of the thyroid gland in his laboratories a t t h e N e w England Deaconess Hospital in Boston. A t that time D r . W A R R E N was also serving as the first Director of the AEC's Division of Biology a n d Medicine a n d therefore helped start our project on the chronic toxicity of I 131 . I n recognition of his m a n y significant D r . W . J . BAIR. A total of about 150 off-site visitors have registered for this symposium, a n d the countries represented a r e : England, France, Belgium, West Germany, India, J a p a n , United A r a b Republic, C a n a d a a n d the United States. O n behalf of Hanford Biology Laboratory you are warmly welcomed a n d have our best wishes for an interesting a n d successful symposium. T h e Invocation was delivered b y E. M E E N A of Tanganyika a n d t h e Union Seminary of New York. * Theological * Copies may be obtained from the Symposium Editor. SYMPOSIUM ON THE BIOLOGY OF RADIOIODINE: STATEMENT OF THE PROBLEM H. D . B R U N E R Division of Biology a n d Medicine, U . S . Atomic Energy Commission, Washington 25, D . C . WHEN Drs. BUSTAD and KORNBERG b