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Progress in Drug Research Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques Vol. 46 Progress in Drug Research Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques Vol. 46 Edited by / Herausgegeben von / Redige par Ernst Jucker, Basel Authors / Autoren / Auteurs Norman K. Hollenberg and Steven W. Graves . Robert B. McCall· William T. Jackson and Jerome H. Fleisch· M. Margaglione, E. Grandone, EP. Mancini and G. Di Minno . N. Seiler, A. Hardy and 1.P. Moulinoux . James Claghorn and Michael D. Lesem· Eric 1. Lien, Arima Das and Linda L. Lien 1996 Birkhauser Verlag Basel· Boston· Berlin Editor: Dr. E. Jucker Steinweg 28 CH-4107 Ettingen Switzerland The Publisher and Editor cannot assume any legal responsibility for information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks, etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, the permission of the copyright holder must be obtained. © 1996 Birkhauser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Softcover reprint of the hardcover 1st edition 1996 Printed on acid-free paper produced from chlorine-free pulp. TCF lSBN-13: 978-3-0348-9861-4 DOl: 10.1007/978-3-0348-8996-4 987654321 e-lSBN-13: 978-3-0348-8996-4 00 Contents· Inhalt· Sommaire Endogenous sodium pump inhibition: Current status and therapeutic opportunities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . By Norman K. Hollenberg and Steven W. Graves 9 Neurotransmitters involved in the central regulation of the cardiovascular system .................................... By Robert B. McCall 43 Development of novel anti-inflammatory agents: A pharmacologic perspective on leukotrienes and their receptors ...... . . By William T. Jackson and Jerome H. Fleisch 115 Drugs affecting plasma fibrinogen levels. Implications for new antithrombotic strategies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . By M. Margaglione, E. Grandone, EP. Mancini and G. Di Minno Aminoglycosides and polyamines: Targets and effects in the mammalian organism of two important groups of natural aliphatic polycations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . By N. Seiler, A. Hardy and J.P. Moulinoux Recent developments in antidepressant agents ............... By James Claghorn and Michael D. Lesem 169 183 243 Immunopharmacological and biochemical bases of Chinese herbal medicine ......................................... By Eric J. Lien, Arima Das and Linda L. Lien 263 Index Sachverzeichnis . Table des matieres, Vol. 46 ........... 281 Index of titles· Verzeichnis der Titel· Index des titres Vol. 1-46 ... 287 Author and paper index· Autoren- und Artikelindex . Index des auteurs et des articles, Vol. 1-46 ............................ 299 Foreword Volume 46 of "Progress in Drug Research" contains seven reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with endogenous sodium pump inhibition, with neurotransmitters involved in the central regulation of the c