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This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.
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Edited by Karlheinz Drauz, Harald Gro¨ger, and Oliver May Enzyme Catalysis in Organic Synthesis Volume 1 Related Titles Whittall, J., Sutton, P. Practical Methods for Biocatalysis and Biotransformations Hardcover ISBN: 978-0-470-51927-1 Tao, J., Lin, G.-Q., Liese, A. Biocatalysis for the Pharmaceutical Industry Discovery, Development, and Manufacturing Hou, C. T., Shaw, J.-F. Biocatalysis and Bioenergy Hardcover ISBN: 978-0-470-13404-7 Gotor, V., Alfonso, I., García-Urdiales, E. (eds.) Asymmetric Organic Synthesis with Enzymes 2008 Hardcover ISBN: 978-3-527-31825-4 Hardcover ISBN: 978-0-470-82314-9 Crabtree, R. H. (ed.) Handbook of Green Chemistry Green Catalysis 2009 Aehle, W. (ed.) Enzymes in Industry Production and Applications 2007 Hardcover ISBN: 978-3-527-31689-2 Hardcover ISBN: 978-3-527-31577-2 Fessner, W.-D., Anthonsen, T. (eds.) Roberts, S. M. Catalysts for Fine Chemical Synthesis Volumes 1-5. Set Modern Biocatalysis Stereoselective and Environmentally Friendly Reactions 2007 Hardcover ISBN: 978-0-470-51605-8 2009 Hardcover SBN: 978-3-527-32071-4 Garcia-Junceda, E. (ed.) Enders, D., Jaeger, K.-E. (eds.) Asymmetric Synthesis with Chemical and Biological Methods 2007 Multi-Step Enzyme Catalysis Hardcover Biotransformations and Chemoenzymatic Synthesis ISBN: 978-3-527-31473-7 2008 Hardcover ISBN: 978-3-527-31921-3 Edited by Karlheinz Drauz, Harald Gröger, and Oliver May Enzyme Catalysis in Organic Synthesis Volume 1 With a Foreword by Herbert Waldmann Third, Completely Revised and Enlarged Edition The Editors Prof. Dr. Karlheinz Drauz Evonik Industries AG Innovation Management Rodenbacher Chaussee 4 63457 Hanau Germany Prof. Dr. Harald Gröger Bielefeld University Organic Chemistry I P.O. box 100131 33501 Bielefeld Germany Dr. Oliver May DSM Innovative Synthesis B.V. Mijnweg 2 6167 AC Geleen The Netherlands All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate. Library of Congress Card No.: applied for British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Bibliographic information published by the Deutsche Nationalbibliothek The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at http://dnb.d-nb.de. # 2012 Wiley-VCH Verlag & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this bo