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Advances in INORGANIC CHEMISTRY Volume 51 ADVISORY BOARD I. Bertini D. M. P. Mingos, FRS Universita´ degli Studi di Firenze Florence, Italy Imperial College of Science, Technology, and Medicine London, United Kingdom A. H. Cowley, FRS J. Reedijk University of Texas Austin, Texas, USA Leiden University Leiden, The Netherlands H. B. Gray A. M. Sargeson, FRS California Institute of Technology Pasadena, California, USA The Australian National University Canberrs, Australia M. L. H. Green, FRS University of Oxford Oxford, United Kingdom Y. Sasaki Hokkaido University Sapporo, Japan D. F. Shriver O. Kahn Institut de Chimie de la Matiere ` Condensee ´ de Bordeaux Pessac, France Andre´ E. Merbach Institut de Chimie Minerale ´ et Analytique Universite´ de Lausanne Lausanne, Switzerland Northwestern University Evanston, Illinois, USA R. van Eldik Universitat ¨ Erlangen-Numberg ¨ Erlangen, Germany K. Wieghardt Max-Planck Institut Mulheim, ¨ Germany Advances in INORGANIC CHEMISTRY Heme-Fe Proteins EDITED BY A. G. Sykes Department of Chemistry The University of Newcastle Newcastle upon Tyne United Kingdom CO-EDITED BY Grant Mauk Faculty of Medicine Department of Biochemistry and Molecular Biology The University of British Columbia, Vancouver, British Columbia, Canada VOLUME 51 San Diego San Francisco New York Boston London Sydney Tokyo This book is printed on acid-free paper. ∞ C 2001 by ACADEMIC PRESS Copyright All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the Publisher. The appearance of the code at the bottom of the first page of a chapter in this book indicates the Publisher’s consent that copies of the chapter may be made for personal or internal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per copy fee through the Copyright Clearance Center, Inc. (222 Rosewood Drive, Danvers, Massachusetts 01923), for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Copy fees for pre-2000 chapters are as shown on the title pages. If no fee code appears on the title page, the copy fee is the same as for current chapters. 0898-8838/01 $35.00 Explicit permission from Academic Press is not required to reproduce a maximum of two figures or tables from an Academic Press chapter in another scientific or research publication provided that the material has not been credited to another source and that full credit to the Academic Press chapter is given. Academic Press A Harcourt Science and Technology Company 525 B Street, Suite 1900, San Diego, California 92101-4495, U.S.A. http://www.apnet.com Academic Press 24-28 Oval Road, London NW1 7DX, UK http://www.hbuk.co.uk/ap/ International Standard Book Number: 0-12-023651-6 PRINTED IN THE UNITED STATES OF AMERICA 99 00 01 02 03 04 QW 9 8 7 6 5 4 3 2 1 CONTENTS Clinical Reactivity of the Active Site of Myoglobin EMMA LLOYD RAVEN AND A. GRANT MAUK I. II. III. IV. V. VI. VII. VIII. IX. X. XI. Introduction Cloning and Expression of Recombinant Myoglobin Active Site Variants of Myoglobin . . . Electron Transfer Reactions of Myoglobin . Peroxidase Activity . . . . . Lipoxygenase Activity . . . . . Monooxygenase Activity . . . . Coupled