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Comp. by: Kkavitha Stage: Proof Chapter No.: FrontMatter Date:31/7/12 Time:13:56:37 Page Number: 1 Title Name: HESKETH Introduction to Cancer Biology A Concise Journey from Epidemiology through Cell and Molecular Biology to Treatment and Prospects This concise overview of the fundamental concepts of cancer biology is ideal for students with little or no background in the field. A digestible summary of global cancer patterns introduces students to the general principles of how cancers arise. Specific key examples are then used to illustrate the role of mutations in perturbing signalling pathways in cells, highlighting general principles without overwhelming students with detail. Later chapters build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Reviews of current therapeutic strategies and the impact of whole genome sequencing bring students up to date with important recent developments in the field. Appendix E summarises the ten major cancers, providing a valuable reference resource, and further reading sections point students towards helpful review articles, offering an easy transition into the scientific literature. Robin Hesketh has been a member of the Biochemistry Department at the University of Cambridge for over 25 years. He has given lecture courses at all undergraduate levels from first-year medicine to fourth-year biochemistry on a wide range of cell and molecular biology topics with a particular focus on cancer. He has also run undergraduate practicals on a variety of themes and for many years gave tutorials in all of the Tripos courses taught by the Biochemistry Department. His major research area is the development of anti-angiogenic strategies for the treatment of cancer. Comp. by: Kkavitha Stage: Proof Chapter No.: FrontMatter Date:31/7/12 Time:13:56:37 Page Number: 2 Title Name: HESKETH Comp. by: Kkavitha Stage: Proof Chapter No.: FrontMatter Date:31/7/12 Time:13:56:37 Page Number: 3 Title Name: HESKETH Introduction to Cancer Biology A Concise Journey from Epidemiology through Cell and Molecular Biology to Treatment and Prospects Robin Hesketh University of Cambridge Comp. by: Kkavitha Stage: Proof Chapter No.: FrontMatter Date:31/7/12 Time:13:56:38 Page Number: 4 Title Name: HESKETH CAMBRIDGE UNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, Sa˜o Paulo, Delhi, Mexico City Cambridge University Press The Edinburgh Building, Cambridge CB2 8RU, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9781107013988 © Robin Hesketh 2013 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2013 Printed in the United Kingdom at the University Press, Cambridge A catalogue record for this publication is available from the British Library Library of Congress Cataloguing in Publication data Hesketh, Robin. Introduction to cancer biology / Robin Hesketh. p. ; cm. Includes bibliographical references and index. ISBN 978-1-107-01398-8 (Hardback) – ISBN 978-1-107-60148-2 (Paperback) I. Title. [DNLM: 1. Neoplasms. 2. Neoplastic Processes. 3. Oncogenes. 4. Sequence Analysis, DNA. QZ 200] 616.990 4–dc23 2012015670 ISBN 978-1-107-01398-8 Hardback ISBN 978-1-107-60148-2 Paperback Additional resources for this publication at www.cambridge.org/9781107013988 Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarante