How We Remember How We Remember Brain Mechanisms of Episodic Memory Michael E. Hasselmo The MIT Press Cambridge, Massachusetts London, England © 2012 Massachusetts Institute of Technology All rights reserved. No part of this book may be reproduced in any form by any electronic or mechanical means (including photocopying, recording, or information storage and retrieval) without permission in writing from the publisher. MIT Press books may be purchased at special quantity discounts for business or sales promotional use. For information, please email
[email protected] or write to Special Sales Department, The MIT Press, 55 Hayward Street, Cambridge, MA 02142. This book was set in Stone Sans and Stone Serif by Toppan Best-set Premedia Limited and was printed and bound in the United States of America. Library of Congress Cataloging-in-Publication Data Hasselmo, Michael E. How we remember : brain mechanisms of episodic memory / Michael E. Hasselmo. p.; cm. Includes bibliographical references and index. ISBN 978-0-262-01635-3 (hardcover : alk. paper) 1. Memory—Physiological aspects. 2. Recollection (Psychology)—Physiological aspects. 3. Brain—Physiology. I. Title. [DNLM: 1. Mental Recall—physiology. 2. Brain—physiology. WL 102] QP406.H37 2012 612.8’2—dc22 2011008719 10 9 8 7 6 5 4 3 2 1 To Chantal, Simone, Nicholas, and the rest of my family Contents Preface ix 1 Behavioral Dynamics of Episodic Memory 1 2 Neural Dynamics of Episodic Memory 3 Coding of Space and Time for Episodic Memory 4 Encoding and Retrieval of Episodic Trajectories 5 Linking Events and Episodes 6 Drug Effects on the Dynamics of Encoding and Retrieval 7 Dynamics of Memory-Guided Behavior 31 83 121 139 Appendix: Mathematical Models of Memory References 297 Author Index 341 Subject Index 349 243 211 173