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Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters! Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago. Chronicling the complete history and variations of CLL-type leukemia, the Second Edition ·reviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias ·analyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL ·examines recent research on the role cytokines and regulatory molecules may play in cross-cell communication ·profiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production ·utilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations ·explores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications ·identifies how to manage infectious and psychiatric complications in patients with CLL ·and much more! Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine! Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.
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This Page Intentionally Left Blank The first edition of this book was published as Chronic Lymphocytic Leukemia: Scientific Advances and Clinical Developments, B. D. Cheson, ed., Marcel Dekker, Inc., 1993. ISBN: 0-8247-0543-2 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-261-8482; fax: 41-61-261-8896 World Wide Web http:/ /www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright 2001 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA Series Introduction The current volume, Chronic Lymphoid Leukemias: Second Edition, Revised and Expanded, is the twenty-sixth in the Basic and Clinical Oncology series. Many of the advances in oncology have resulted from close interaction between the basic scientist and the clinical researcher. The current volume illustrates the success of this relationship as demonstrated by new insights into clinical drug resistance and means of circumventing this potential obstacle to effective cancer treatment. As editor of the series, my goal is to recruit volume editors who not only have established reputations based on their outstanding contributions to oncology, but who also have an appreciation for the dynamic interface between the laboratory and the clinic. To date, the series has con