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The field of biomedical research on alcoholism has developed at an astonishing speed in recent years. Today, new medications and treatment strategies are available and new leads are currently tested in multi-center trials. This book gives a comprehensive overview about different neurotransmitter/peptide systems involved in craving and relapse behavior and critically describes the clinical application of new anti-craving and anti-relapse compounds. The editors - a preclinical researcher and a clinical researcher, together with some of the most distinguished experts in the field - compiled the most recent available preclinical and clinical data, offering a thorough picture on modern relapse prevention. Undoubtedly, this book sets out to provide an all-encompassing overview about the topic, which will be of interest to the preclinical researcher, the clinician as well as to the patient who wants to learn more.
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(( 3. Umbruch 2.11.2004 )) Milestones in Drug Therapy MDT Series Editors Prof. Michael J. Parnham, PhD Senior Scientific Advisor PLIVA Research Institute Ltd Prilaz baruna Filipovic´ a 29 HR-10000 Zagreb Croatia Prof. Dr. J. Bruinvels Sweelincklaan 75 NL-3723 JC Bilthoven The Netherlands Drugs for Relapse Prevention of Alcoholism Edited by R. Spanagel and K.F. Mann Birkhäuser Verlag Basel · Boston · Berlin Editors Rainer Spanagel Universität Heidelberg Abteilung für Psychopharmakologie J5, Zentralinstitut für Seelische Gesundheit 68159 Mannheim Germany Karl F. Mann Klinik für Abhängiges Verhalten und Suchtmedizin J5, Zentralinstitut für Seelische Gesundheit 68159 Mannheim Germany Advisory Board J.C. Buckingham (Imperial College School of Medicine, London, UK) R.J. Flower (The William Harvey Research Institute, London, UK) G. Lambrecht (J.W. Goethe Universität, Frankfurt, Germany) Library of Congress Cataloging-in-Publication Data Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de ISBN 3-7643-0214-3 Birkhäuser Verlag, Basel - Boston - Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2005 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TFC ∞ Cover illustration: ((folgt)) Printed in Germany ISBN 3-7643-0214-3 987654321 www. birkhauser.ch V Contents List of contributors ...................................... VII ............................................... XI Griffith Edwards History of prevention of relapse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Preface Rainer Spanagel How to measure relapse in animals .......................... 13 Henry R. Kranzler and Howard Tennen How to measure relapse in humans . . . . . . . . . . .