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The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.
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Experimental Models in Serotonin Transporter Research The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. In this book, an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research. a l l a n v . k a l u e f f is Assistant Professor of Physiology in the Department of Physiology and Biophysics at the Georgetown University Medical Center, Washington DC, USA. His research has been recognized by numerous prestigious scientific awards, and has focused on the role of the serotonin transporter as a contributor to neuropsychiatric disorders in various animal models. j u s t i n l . l a p o r t e worked at the National Institute of Mental Health (Bethesda, USA) and employed behavioral pharmacology and molecular genetics approaches to elucidate the pathogenetic mechanisms of psychiatric disorders with a specific focus on the role of the serotonin transporter. Experimental Models in Serotonin Transporter Research allan v. kalueff Georgetown University Medical Center justin l. laporte National Institute of Mental Health CAMBRIDGE UNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, Sa ˜o Paulo, Delhi, Dubai, Tokyo Cambridge University Press The Edinburgh Building, Cambridge CB2 8RU, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521514873 # A. V. Kalueff and J. L. LaPorte 2010 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2010 Printed in the United Kingdom at the University Press, Cambridge A catalogue record for this publication is available from the British Library Library of Congress Cataloging-in-Publication Data Experimental models in serotonin transporter research / [edited by] Allan V. Kalueff, Justin L. Laporte. p. ; cm Includes bibliographical references and index. ISBN 978-0-521-51487-3 (hardback) 1. Serotonin. 2. Carrier proteins. 3. Serotoninergic mechanisms. I. Kalueff, Allan V. II. LaPorte, Justin L. III. Title. [DNLM: 1. Ser