Advances in Molecular and Cellular Microbiology 18 Antimicrobial Peptides Discovery, Design and Novel Therapeutic Strategies Edited by Guangshun Wang, PhD Eppley Institute University of Nebraska Medical Center Omaha, Nebraska, USA Advances in Molecular and Cellular Microbiology Through the application of molecular and cellular microbiology we now recognize the diversity and dominance of microbial life forms that exist in all environments on our planet. These microbes have many important planetary roles, but for humans a major problem is their ability to colonize our tissues and cause disease. The same techniques of molecular and cellular microbiology have been applied to the problems of human and animal infection since the 1990s and have proved to be immensely powerful tools in elucidating how microorganisms cause human pathology. This series has the aim of providing information on the advances that have been made in the application of molecular and cellular microbiology to specific organisms and the diseases they cause. The series is edited by researchers active in the application of molecular and cellular microbiology to human disease states. Each volume focuses on a particular aspect of infectious disease and will enable graduate students and researchers to keep up with the rapidly diversifying literature in current microbiological research. Series Editors Professor Brian Henderson University College London Professor Michael Wilson University College London Titles Available from CABI 17. Helicobacter pylori in the 21st Century Edited by Philip Sutton and Hazel M. Mitchell 18. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies Edited by Guangshun Wang Titles Forthcoming from CABI Stress Response in Pathogenic Bacteria Edited by Stephen Kidd Lyme Disease: an Evidence-based Approach Edited by John Halperin Tuberculosis: Molecular Techniques in Diagnosis and Treatment Edited by Timothy McHugh Microbial Metabolomics Edited by Silas Villas-Bôas and Katya Ruggiero Earlier titles in the series are available from Cambridge University Press (www.cup.cam.ac.uk). CABI is a trading name of CAB International CABI Head Office Nosworthy Way Wallingford Oxfordshire, OX10 8DE UK CABI North American Office 875 Massachusetts Avenue 7th Floor Cambridge, MA 02139 USA Tel: +44 (0)1491 832111 Fax: +44 (0)1491 833508 E-mail:
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[email protected] © CAB International 2010. All rights reserved. No part of this publication may be reproduced in any form or by any means, electronically, mechanically, by photocopying, recording or otherwise, without the prior permission of the copyright owners. A catalogue record for this book is available from the British Library, London, UK. Library of Congress Cataloging-in-Publication Data Antimicrobial peptides : discovery, design, and novel therapeutic strategies / edited by Guangshun Wang. p. ; cm. -- (Advances in molecular and cellular microbiology ; 18) Includes bibliographical references and index. ISBN 978-1-84593-657-0 (alk. paper) 1. Peptide antibiotics. I. Wang, Guangshun. II. Series: Advances in molecular and cellular microbiology ; 18. [DNLM: 1. Antimicrobial Cationic Peptides. 2. Anti-Infective Agents. 3. Drug Design. 4. Immunity, Innate. QU 68 A6308 2010] RS431.P37A575 2010 615’.1--dc22 2010016796 ISBN-13: 978 1 84593 657 0 Commissioning editor: Rachel Cutts Production editor: Tracy Head Typeset by Columns Design Ltd, Reading, UK. Printed and bound in the UK