Current Topics in Behavioral Neurosciences Series Editors: Mark Geyer, La Jolla, CA, USA Bart Ellenbroek, Hamburg, Germany Charles Marsden, Nottingham, UK About this series Current Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats. With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on ‘‘translational medicine’’ and cutting-edge technologies. Preclinical and clinical trials for the development of new diagnostics and therapeutics as well as prevention efforts are covered whenever possible. Husseini K. Manji l Carlos A. Zarate Editors Behavioral Neurobiology of Bipolar Disorder and its Treatment Editors Prof. Dr. Husseini K. Manji Johnson & Johnson Pharmaceutical Research & Development, LLC Trenton Habourton Road 1125 08560 Titusville New Jersey E32000 USA
[email protected] Prof. Dr. Carlos A. Zarate Jr. Experimental Therapeutics and Pathophysiology Branch Intramural Research Program National Institute of Mental Health National Institutes of Health Mark O. Hatfield Clinical Research Center 10 Center Dr., Unit 7 SE, Rm 7 3465 Bethesda, Maryland 20892 USA
[email protected] ISSN 1866 3370 e ISSN 1866 3389 ISBN 978 3 642 15756 1 e ISBN 978 3 642 15757 8 DOI 10.1007/978 3 642 15757 8 Springer Heidelberg Dordrecht London New York # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution unde