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Targeted radiotherapy relies on and exploits characteristics of cancer cells to attack tumors. Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.
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MONOCLONAL ANTIBODY AND PEPTIDE-TARGETED RADIOTHERAPY OF CANCER Edited by Raymond M. Reilly MONOCLONAL ANTIBODY AND PEPTIDE-TARGETED RADIOTHERAPY OF CANCER MONOCLONAL ANTIBODY AND PEPTIDE-TARGETED RADIOTHERAPY OF CANCER Edited by Raymond M. Reilly Copyright 2010 by John Wiley & Sons, Inc. All rights reserved. Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6008, or online at http://www.wiley.com/go/permission. Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. For general information on our other products and services or for technical support, please contact our Customer Care Department within the United States at (800) 762-2974, outside the United States at (317) 572-3993 or fax (317) 572-4002. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic formats. For more information about Wiley products, visit our web site at www.wiley.com. Library of Congress Cataloging-in-Publication Data: Monoclonal antibody and peptide-targeted radiotherapy of cancer / edited by Raymond M. Reilly. p. ; cm. Includes bibliographical references and index. ISBN 978-0-470-24372-5 (cloth) 1. Cancer–Radioimmunotherapy. 2. Monoclonal antibodies–Therapeutic use. 3. Tumor proteins. I. Reilly, Raymond. [DNLM: 1. Neoplasms–radiotherapy. 2. Antibodies, Monoclonal–therapeutic use. 3. Peptides–therapeutic use. 4. Radioimmunotherapy–methods. 5. Receptors, Peptide–therapeutic use. QZ 269 M751 2010] RC271.R26M66 2010 2009045879 616.990 40642–dc22 Printed in Singapore 10 9 8 7 6 5 4 3 2 1 To my mother, who always used to ask me, What is