SCIENCE OF PAIN This page intentionally left blank SCIENCE OF PAIN Editors Dr Allan I. Basbaum University of California, San Francisco, CA, USA Dr M. Catherine Bushnell McGill University, Montreal, Quebec, Canada AMSTERDAM BOSTON HEIDELBERG LONDON NEW YORK OXFORD PARIS SAN DIEGO SAN FRANCISCO SINGAPORE SYDNEY TOKYO Academic Press is an imprint of Elsevier The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2009 Copyright ª 2009 Elsevier Inc. All rights reserved The following article is a US Government work in the public domain and is not subject to copyright: PSYCHOPHYSICS OF PAIN No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (þ44) (0) 1865 843830; fax (þ44) (0) 1865 853333; email:
[email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein, Because of rapid advances in the medical sciences, in particular, independent verfication of diagnoses and drug dosages should be made British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Catalog Number: 2008930958 ISBN: 978-012-374625-2 For information on all Elsevier publications visit our website at books.elsevier.com Printed and bound in Slovenia 07 08 09 10 11 10 9 8 7 6 5 4 3 2 1 Working together to grow libraries in developing countries www.elsevier.com | www.bookaid.org | www.sabre.org Contents Introduction ix 1 The Adequate Stimulus R D Treede