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Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.
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ADVANCES IN MOLECULAR AND CELL BIOLOGY CELL Volume 26 This Page Intentionally Left Blank ADVANCES IN MOLECULAR AND CELL BIOLOGY CELL POLARITY Series Editor: E. EDWARD BITTAR Department of Physiology University of Wisconsin Madison, Wisconsin Guest Editor: JAMES R. BARTLES Department of Cell and Molecular Biology hbrthwestern University School of Medicine Chicago, lllinois ~ VOLUME 26 1998 @JAI PRESS INC. Stamford, Connecticut London, England Copyright 0 19981Al P R K S INC. 7 00 Prospect Street Stamford, Connecticut 06901 )A1 PRESS LJD. 38 Javistock Street Covent Garden London WC2f 7PB England All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any way, or by any means, electronic, mechanical, photocopying, recording, filming or otherwise without prior permission in writing from the publisher. ISBN: 0-7623-0381-6 Manufactured in the United States of America CONTENTS vii LIST OF CONTRIBUTORS PREFACE James R. Bartles ix CELL POLARITY IN THE BUDDING YEAST SACCHAROMYCES CEREVlSlAE Christine Costigan and Michael Snyder 1 CELL POLARITY AND MOUSE EARLY DEVELOPMENT Tom P. Flemin Elizabeth Butler, lane Collins, Bfav Sheth, and Arthur E. Wild 67 SIGNALS AND MECHANISMS OF SORTING IN EPITHELIAL POLARITY Cara 1. Cottardi and Michael]. Caplan 95 THE GENERATION OF POLARITY IN NEURONAL CELLS Sharon K. Powell and Rodolfo 1. Rivas 133 POLARITY AND DEVELOPMENT OF THE CELL SURFACE IN SKELETAL MUSCLE Annelise 0.lorgensen 157 POLARITY AND POLARIZATION OF FIBROBLASTS IN CULTURE Albert K . Harris 201 INDEX 253 V This Page Intentionally Left Blank LIST OF CONTRIBUTORS Elizabeth Butler Department of Obstetrics and Gynecology University of Southampton Southampton, England Michael 1. Caplan Department of Cellular and Molecular Physiology Yale University School of Medicine New Haven, Connecticut lane Collins Department of Pathology University of Southampton Southampton, England Christine Costigan Department of Biology Yale University New Haven, Connecticut Tom P. Fleming School of Biological Sciences University of Southampton Southampton, England Cara 1. Cottardi Department of Cell Biology Memorial Sloan Kettering Cancer Center New York. New York Albert K. Harris Department of Biology University of North Carolina Chapel Hill, North Carolina Annelise 0.Jorgensen