E-Book Overview
The validation and standardization of fluorescence methods is still in its infancy as compared to other prominent analytical and bioanalytical methods. Appropriate quality assurance standards are however a prerequisite for applications in highly regulated fields such as medical diagnostics, drug development, or food analysis.
For the first time, a team of recognized international experts has documented the present status of quality assurance in fluorescence measurements, and outlines concepts for establishing standards in this field.
This second of two volumes covers applications of fluorescence for bioanalysis and biomedical diagnostics.
E-Book Content
6 Springer Series on Fluorescence Methods and Applications Series Editor: O. S. Wolfbeis Springer Series on Fluorescence Series Editor: O. S. Wolfbeis Recently Published and Forthcoming Volumes Standardization and Quality Assurance in Fluorescence Measurements II Bioanalytical and Biomedical Applications Volume Editor: Resch-Genger, U. Vol. 6, 2008 Standardization and Quality Assurance in Fluorescence Measurements I Techniques Volume Editor: Resch-Genger, U. Vol. 5, 2008 Fluorescence of Supermolecules, Polymeres, and Nanosystems Volume Editor: Berberan-Santos, M. N. Vol. 4, 2007 Fluorescence Spectroscopy in Biology Volume Editor: Hof, M. Vol. 3, 2004 Fluorescence Spectroscopy, Imaging and Probes Volume Editor: Kraayenhof, R. Vol. 2, 2002 New Trends in Fluorescence Spectroscopy Volume Editor: Valeur, B. Vol. 1, 2001 Standardization and Quality Assurance in Fluorescence Measurements II Bioanalytical and Biomedical Applications Volume Editor: Ute Resch-Genger With contributions by P. E. Barker · F. Brakenhoff · V. Buschmann · A. Dixon · A. Esposito F. W. Frueh · A. K. Gaigalas · K. Garsha · H. C. Gerritsen F. M. Goodsaid · H.-J. He · T. Heinlein · I. Hemmilä · F. Hillger K. Hoffmann · R. A. Hoffman · M. J. Holden · D. Hyde · F. Koberling C. Maercker · J. N. Miller · D. Nettels · W. Nietfeld · R. Nitschke V. Ntziachristos · E. P. Petrov · U. Resch-Genger · H. Schneckenburger B. Schuler · P. Schwille · M. Seydack · L. Shi · W. Tong · L. Wang R. Wolleschensky · F. S. Wouters · Y. Xiao · Y. Zong · S. Zou R. M. Zucker · J. Zwier 123 Fluorescence spectroscopy, fluorescence imaging and fluorescent probes are indispensible tools in numerous fields of modern medicine and science, including molecular biology, biophysics, biochemistry, clinical diagnosis and analytical and environmental chemistry. Applications stretch from spectroscopy and sensor technology to microscopy and imaging, to single molecule detection, to the development of novel fluorescent probes, and to proteomics and genomics. The Springer Series on Fluorescence aims at publishing state-of-the-art articles that can serve as invaluable tools for both practitioners and researchers being active in this highly interdisciplinary field. The carefully edited collection of papers in each volume will give continuous inspiration for new research and will point to exciting new trends. ISBN 978-3-540-70570-3 DOI 10.1007/978-3-540-70571-0 e-ISBN 978-3-540-70571-0 Springer Series on Fluorescence ISSN 1617-1306 Library of Congress Control Number: 2008934168 c 2008 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecu