ADVANCES IN GENETICS VOLUME 25 This Page Intentionally Left Blank ADVANCES IN GENETICS €dited by E. W. CASPARI JOHN G. SCANDALIOS Department of Biology University of Rochester Rochestel; New York Department of Genetics North Carolina State University Raleigh, North Carolina VOLUME 25 ACADEMIC PRESS, INC. Hnrcourt Brace Jovanovich, Publishers San Diego New York Berkeley Boston London Sydney Tokyo Toronto COPYRIGHT 0 1988 BY ACADEMICPRESS, INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMlTED IN ANY FORM OR BY ANY MEANS. ELECTRONIC OR MECHANICAL. INCLUDING PHOTOCOPY, RECORDING. OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. 1250 Sixth Avenue San Diego, California 92101 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) LTD. 24-28 Oval Road, London NWl 7DX LIBRARYOF CONGRESS CATALOG CARD NUMBER: 47-30313 ISBN 0-12-017625-4 (alk. paper) PRINTED IN THE UNITED STATES OF AMERICA 88899091 9 8 7 6 5 4 3 2 1 CONTENTS Transferrin: Evolution and Genetic Regulation of Expression . BARBARA H BOWMAN. FUNMEI YANG.AND GWENWLYN S . ADRIAN I. I1. I11. IV. V. Introduction ......................................................... Properties of Human lhnsferrin ....................................... Evolution of the Transferrin Gene ...................................... Expression of TF Gene ................................................ Conclusions .......................................................... References ........................................................... 1 2 2 12 29 30 The Drosophila Alcohol Dehydrogenase Gene-Enzyme System . GEOFFREY K CHAMBERS I. I1 I11. IV V VI . VII VIII . IX X Introduction ......................................................... . Classical Genetics of Adh .............................................. Molecular Genetics of Adh ............................................ . Developmental Genetics of Adh ........................................ . Quantitative Genetics of Adh ........................................... The Adh Gene Product: Dmsophika Alcohol Dehydrogenase ................ . Ecological Genetics of Adh ............................................ Evolutionary Genetics of Adh .......................................... . Population Genetics of Adh ............................................ . Conclusions .......................................................... References ........................................................... 40 41 44 49 53 58 65 72 76 86 87 Genetics Research on Braconid Wasps DANIEL S. GROSCH I. I1 I11. IV. V. VI Introduction ......................................................... . Developmental Aspects ................................................ . Experiments with Adults ............................................... Experiments with Radiations ........................................... Experiments with Chemical Agents ..................................... Concluding Remarks .................................................. References ........................................................... Note Added in Proof .................................................. V 110 111 126 146 164 174 175 184 vi CONTENTS The Variable Mitochondrial Genome of Ascomycetes: Organization. Mutational Alterations. and Expression KLAUSWOLFAND LUIGIDELGIUDICE I . Introduction ......................................................... I1. Mitochondrial Genome Organization .................................... I11. Mitochondri