E-Book Overview
This highly successful textbook, acclaimed for its comprehensiveness, accuracy, and its many excellent illustrations and photographs now comes in its second edition. Completely revised and substantially extended it offers:
– New chapter on Tandem Mass Spectrometry covering instrumentation, methods for ion activation (CID, ECD, ETD, IRMPD), and applications
– New chapter on Ambient Mass Spectrometry (DART, DESI, and more)
– New chapter on Inorganic Mass Spectrometry including element speciation and imaging
– Learning Objectives for all chapters
– Advanced Instrumentation such as orbitraps, linear ion traps, tandem TOFs, FT-ICR and the highly variable hybrid instruments
– Updated Problems and Solutions website (www.ms-textbook.com)
Jürgen H. Gross provides in-depth explanations of concepts, methods, and techniques. Students and professionals alike are guided step-by-step from the basics to the successful application of mass spectrometry. Starting from the very principles of gas-phase ion chemistry, isotopic composition, and accurate mass, Jürgen H. Gross leads through the design of all types of mass analyzers and ionization methods to mass spectral interpretation and coupling techniques. His book offers a balanced mixture of practice-oriented information and theoretical background supported by a wealth of references.
From reviews of the previous edition:
“…one of the best textbooks on mass spectrometry I have seen so far.” International Journal of Mass Spectrometry
“…can be recommended unreservedly as a textbook and reference source…” Angewandte Chemie, International Edition
E-Book Content
Mass Spectrometry Second Edition
Jürgen H. Gross
Mass Spectrometry A Textbook Second Edition
Foreword by Peter Roepstorff
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Jürgen H. Gross Institute of Organic Chemistry Heidelberg University Im Neuenheimer Feld 270 69120 Heidelberg Germany email:
[email protected]
ISBN 978-3-642-10709-2 e-ISBN 978-3-642-10711-5 DOI 10.1007/978-3-642-10711-5 Springer Heidelberg Dordrecht London New York c Springer-Verlag Berlin Heidelberg 2004, 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Shortly after having graduated in 1966 and just employed as a research assistant in a protein chemistry laboratory, my very first contact with mass spectrometry happened when I stumbled on a paper by Michael Barber, the later discoverer of fast atom bombardment (FAB). Together with a French group he had determined the covalent structure of an almost 1.4 kDa complex peptidolipid called fortuitine by using mass spectrometry. Fascinated by this to me unknown technique, I felt that MS