Toxicological Profiles - Hexachloroethane

Perchloroethane; carbon hexachloride; 1,1,1,2,2,2- hexachloroethane; hexachloroethylene; HCE; Avlothane; Distokal; Distopan; Distopin; Egitol; Falkitol; Fasciolin; Mottenhexe; Phenohep TOXICOLOGICAL PROFILE FOR HEXACHLOROETHANE Prepared by: Sciences International, Inc. Under Subcontract to: Research Triangle Institute Under Contract No. 205-93-0606 Prepared for: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 1997 HEXACHLOROETHANE DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. HEXACHLOROETHANE UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 HEXACHLOROETHANE CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Cassandra Smith-Simon, M.S. ATSDR, Division of Toxicology, Atlanta, GA Joyce M. Donohue, Ph.D. Life Systems, Inc., Arlington, VA Carol Eisenmann, Ph.D. Sciences International, Inc., Alexandria, VA THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1. Green Border Review. Green Border review assures the consistency with ATSDR policy. 2. Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. HEXACHLOROETHANE PEER REVIEW A peer review panel was assembled for Hexachloroethane. The panel consisted of the following members: 1. 2. 3. Mr. Bruce Jacobs, General Physics Corporation, Edgewood, MD Mr. Lyman Skory, Private Consultant, Midland, Michigan Dr. Peter Van Voris, Senior Program Manager, Richland, Washington These experts collectively have knowledge of hexachloroethane's physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(I)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed the peer reviewers' comments and determined which comments will be included in the profile. A listing of the peer reviewers' comments not incorporated in the profile, with a brief explanation of the rationale for their exclusion, exists as part of the administrative record for this compound. A list of databases reviewed and a list of unpublished documents cited are also included in the administrative record. The citation of the peer review panel should not be understood to imply its approval of the profile's final content. The responsibility for the content of this profile lies with the ATSDR. HEXACHLOROETHANE CONTENTS FOREWORD CONTRIBUTORS PEER REVIEW LIST OF FIGURES LIST OF TABLES 1. PUBLIC HEALTH STATEMENT 1.1 WHAT IS HEXACHLOROETHANE? 1.2 WHAT HAPPENS TO HEXACHLOROETHANE WHEN IT ENTERS THE ENVIRONMENT? 1.3 HOW MIGHT I BE EXPOSED TO HEXACHLOROETHANE? 1.4 HOW CAN HEXACHLOROETHANE ENTER AND LEAVE MY BODY? 1.5 HOW CAN HEXACHLOROETHANE AFFECT MY HEALTH? 1.6 IS THERE A ME