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TOXICOLOGICAL PROFILE FOR DISULFOTON Ethylthiodemeton; M-74; thiodemeton; Di-Syston; Dithiosystex; Solvirex ENT 23347; Frumin AL
Prepared by: Research Triangle Institute Under Subcontract No. 205-93-0606 Prepared for:
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry
August 1995
DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry.
UPDATE STATEMENT This edition supersedes any previously released draft or final profile. Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333
CONTRIBUTORS CHEMICAL MANAGERS(S)/AUTHOR(S): Nickolette Roney ATSDR, Division of Toxicology, Atlanta, GA Sharon Wilbur, M.A. Research Triangle Institute, Research Triangle Park, NC THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS:
1. Green Border Review. Green Border review assures consistency with ATSDR policy. 2. Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying and points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. 4. Quality Assurance Review. The quality Assurance Branch assures that consistency across profiles is maintained, identifies any significant problems in format or content, and establishes that Guidance has been followed.
PEER REVIEW A peer review panel was assembled for disulfoton. The panel consisted of the following members: 1. Dr. William Buck, Private Consultant, Consul-Tox, Inc., Tolono, Illinois; 2. Dr. Lucio Costa, Professor and Director, Toxicology Program, School of Public Health and Community Medicine, Department of Environmental Health, University of Washington, Seattle, Washington; and 3. Dr. Casey Robinson, Professor of Pharmacodynamics and Toxicology, College of Pharmacy, Health Science Center, University of Oklahoma, Oklahoma City, Oklahoma. These experts collectively have knowledge of disulfoton’s physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(i)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed the peer reviewers’ comments and determined which comments will be included in the profile. A listing of the peer reviewers’ comments not incorporated in the profile, with a brief explanation of the rationale for their exclusion, exists as part of the administrative record for this compound. A list of databases reviewed and a list of unpublished documents cited are also included in the administrative record.
The citation of peer review panel should not be understood to imply its approval of the profile’s final content. The responsibility for the content of this profile lies with the ATSDR.
FOREWORD This toxicological profile is prepared in accordance with guidelines developed by ATSDR and EPA. The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as nece